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MEPENZOLATE BROMIDE

MEPENZOLATE BROMIDE Structure
MEPENZOLATE BROMIDE
  • CAS No.76-90-4
  • Chemical Name:MEPENZOLATE BROMIDE
  • CBNumber:CB8305871
  • Molecular Formula:C21H26BrNO3
  • Formula Weight:420.34
  • MOL File:76-90-4.mol
MEPENZOLATE BROMIDE Property
  • Melting point 228-229°C dec.
  • storage temp. Inert atmosphere,Room Temperature
  • solubility DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
  • form Solid
  • color White to Off-White
  • FDA UNII APX8D32IX1
  • ATC code A03AB12
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :TN5710000
  • Toxicity :LD50 orally in rats: 742±47 mg/kg (Goldenthal)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P501
MEPENZOLATE BROMIDE Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: M5651
  • Product name : Mepenzolate bromide
  • Purity: analytical standard
  • Packaging: 5G
  • Price: ₹7415.13
  • Updated: 2022/06/14
  • Buy: Buy

MEPENZOLATE BROMIDE Chemical Properties,Usage,Production

  • Chemical Properties Crystalline Solid
  • Originator Cantil,Merrell National,US,1956
  • Uses Used as an anticholinergic
  • Definition ChEBI: Mepenzolate bromide is a diarylmethane.
  • Manufacturing Process A mixture containing 8 g (0.06 mol) of N-methyl-3-chloro-piperidine and 13.6 g (0.06 mol) of benzilic acid in 50 cc of anhydrous isopropyl alcohol was refluxed for 3 days; the isopropyl alcohol was removed by distillation in vacuo, the residue treated with dilute aqueous hydrochloric acid and the aqueous acid mixture extracted repeatedly with ether. The aqueous phase was separated, made strongly alkaline with 20% aqueous sodium hydroxide and extracted with ether. The ether extracts were dried with potassium carbonate and distilled; the product was collected at 175° to 176°C (0.03 mm), yield 11.5 g (59 %).The ester base thus prepared was then dissolved in 75 cc of isopropyl alcohol and 3.4 g (0.037 mol) methyl bromide added. The reaction mixture was allowed to stand at 30°C for 2 days and the product isolated by filtration, yield, 13 g (87%), MP 228° to 229°C dec.
  • Therapeutic Function Spasmolytic
  • General Description Mepenzolate bromide, 3-hydroxy-1,1-dimethylpiperidinium bromide benzilate (Cantil),has an activity about one half that of atropine in reducingACh-induced spasms of the guinea pig ileum. The selectiveaction on colonic hypermotility is said to relieve pain, cramps,and bloating and to help curb diarrhea.
  • Pharmacology Mepenzolate inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used in place of other drugs for treating stomach ulcers and inflammation of the intestine. Synonyms of this drug are cantil and eftoron.
  • Synthesis Mepenzolate, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl piperidinium bromide (14.1.13), is synthesized by esterification of benzilic acid with 1-methyl-3- chloropiperidine and subsequent reaction of the resulting ester (14.1.12) with methyl bromide [14,15].

    Synthesis_76-90-4

MEPENZOLATE BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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MEPENZOLATE BROMIDE Spectrum
76-90-4, MEPENZOLATE BROMIDERelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • CANTIL
  • 抑制剂
  • 高端化学
  • 有机化工原料
  • 小分子抑制剂
  • MEA - MES
  • Analytical Standards
  • Analytical Chromatography Product Catalog
  • Alphabetic
  • C21H26BrNO3
  • 3-(2-羟基-2,2-二苯乙氧基)-1,1-二甲基哌啶-1-溴化铵
  • 溴美喷酯 标准品
  • 溴美喷酯
  • 溴化甲哌酯
  • 双苯甲胍佐酯
  • 宁胃适
  • 甲哌佐酯
  • 溴化甲呱佐酯
  • 76-90-4
  • Piperidinium, 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1,1-dimethyl-, bromide (1:1)
  • HCAR2,PUMA-G,inhibit,Muscarinic acetylcholine receptor,Inhibitor,hM3R,gastrointestinal,Chronic,HCA2,muscarinic,HM74A,mAChR,orally,pulmonary,COPD,Mepenzolate Bromide,obstructive,GPR109A,Mepenzolate,bronchodilatory,hypermotility,anti-inflammatory,hM2R
  • (1,1-dimethylpiperidin-1-ium-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide
  • 3-(2-Hydroxy-2,2-diphenylacetoxy)-1,1-dimethylpiperidin-1-ium bromide
  • Mepenzolate Bromide (200 mg)
  • Eftoron
  • Atenecolin-M
  • Trancolon
  • Piperidinium, 3-hydroxy-1,1-dimethyl-, bromide, benzilate (8CI)
  • Piperidinium, 3-[(hydroxydiphenylacetyl)oxy]-1,1-dimethyl-, bromide (9CI)
  • NSC 4358
  • Delevil
  • Colum
  • Colopiril
  • Colibantil
  • Cantilon
  • Cantilaque
  • 3-Hydroxy-1,1-dimethylpiperidinium bromide benzilate (6CI, 7CI)
  • 1-Methyl-3-piperidyl benzilate methylbromide
  • 3-benziloyloxy-1,1-dimethylpiperidinium bromide
  • 3-HYDROXY-1,1-DIMETHYLPIPERIDINIUM BROMIDE BENZILATE
  • 3-[(HYDROXY-DIPHENYLACETYL)OXY]-1,1-DIMETHYLPIPERIDINIUM BROMIDE
  • MEPENZOLATE BROMIDE
  • cantril
  • cantil
  • piperidinium,3-hydroxy-1,1-dimethyl-,bromide,benzilate
  • n-methyl-3-piperidyldiphenylglycolatemethobromide
  • n-methyl-3-piperidylbenzilatemethylbromide
  • n-methyl-3-piperidylbenzilatemethobromide
  • mepenzolate
  • jb340
  • gastropidil
  • benzilicacid,esterwith3-hydroxy-1,1-dimethylpiperidiniumbromide
  • benzilicacid,1-methyl-3-piperidylestermethobromide

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