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BROMOPRIDE

BROMOPRIDE Structure
BROMOPRIDE
  • CAS No.4093-35-0
  • Chemical Name:BROMOPRIDE
  • CBNumber:CB8288660
  • Molecular Formula:C14H22BrN3O2
  • Formula Weight:344.25
  • MOL File:4093-35-0.mol
BROMOPRIDE Property
  • Melting point 148-150?C
  • Boiling point 435.8±45.0 °C(Predicted)
  • Density 1.4132 (rough estimate)
  • refractive index 1.6200 (estimate)
  • storage temp. 2-8°C
  • solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 13.84±0.46(Predicted)
  • color White to Off-White
  • FDA UNII 75473V2YZK
  • ATC code A03FA04
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :20/21/22
  • Safety Statements  :36
  • WGK Germany  :3
  • RTECS  :BZ3280000
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H312-H332
  • Precautionary statements P280

BROMOPRIDE Chemical Properties,Usage,Production

  • Description Bromopride is a dopamine D2 receptor antagonist (Ki = 14 nM). It binds to bovine anterior pituitary membranes with an IC50 value of 2.13 μM. Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively). It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg. Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.
  • Chemical Properties White Solid
  • Originator Praiden,Italchemi,Italy,1977
  • Uses An antiemetic.Bromopride is used in method and a system for analyzing neuropharmacology of a drug.
  • Definition ChEBI: 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide is a member of benzamides.
  • Manufacturing Process To 119 g (0.45 mol) of N-(2-diethylaminoethyl)-2-methoxy-4-aminobenzamide dissolved in 200 cc of acetic acid are added in the cold in small portions 69 g of acetic anhydride (0.45 mol + 50% excess). The starting material is made by esterifying 4-aminosalicylic acid with methanol, then acetylating with acetic anhydride and then methylating with dimethyl sulfate. The solution obtained is heated for 2 hours on a water bath and then boiled for 15 minutes. It is cooled at 25°C. While agitating constantly and maintaining the temperature between 25° and 30°C, there is added to the solution drop by drop 72 g of bromine dissolved in 60 cc of acetic acid. It is agitated for one hour. The mixture obtained is added to one liter of water and the base is precipitated by the addition of 30% soda, The precipitated base is extracted with 40 cc of methylene chloride. After evaporation of the solvent, the residue is boiled for two hours with 390 g of concentrated hydrochloric acid in 780 cc of water. It is cooled, diluted with one liter of water, 12 g of charcoal are added, and the mixture filtered. The base is precipitated with 30% soda. The N-(2- diethylaminoethyl)-2-methoxy-4-amino-5-bromobenzamide formed crystallizes, is centrifuged and washed with water. A yield of 85 g of base having a melting point of 129°-130°C is obtained.
    To produce the dihydrochloride, the free base is dissolved in 110 cc of absolute alcohol, 9.6 g of dry hydrochloric acid dissolved in 35 cc of alcohol are added, followed by 2.8 cc of water. The dihydrochloride precipitates, is centrifuged, washed, and dried at 40°C. It was a solid white material having a melting point of 134°-135°C.
  • Therapeutic Function Antiemetic
BROMOPRIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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BROMOPRIDE Spectrum
4093-35-0, BROMOPRIDERelated Search:
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  • C14H22BrN3O2
  • 溴灭吐灵,10 MM DMSO 溶液
  • 奥必利-13C-D3
  • 溴溴化物13C-D3
  • 溴溴化物
  • 4-氨基-5-溴-N-(2-(二乙氨基)乙基)-2-甲氧基苯甲酰胺
  • 溴灭吐灵(溴必利)
  • 溴灭吐灵
  • 甲氧溴苯酰胺
  • 溴达利
  • 溴必利
  • 胃本甲氧溴苯酰胺
  • 扑罗扑利
  • 奥必利
  • 4093-35-0
  • Bromopride, 10 mM in DMSO
  • Bromopride in methanol
  • Inhibitor,Bromopride,Dopamine Receptor,inhibit
  • BromoprideQ: What is Bromopride Q: What is the CAS Number of Bromopride Q: What is the storage condition of Bromopride Q: What are the applications of Bromopride
  • 4-AMINO-5-BROMO-N-[2-(DIETHYL-AMINO)ETHYL-O-ANISAMIDE
  • Viadil
  • Valopride
  • val13081
  • VAL 13081
  • o-Anisamide, 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-
  • n-(diethylaminoethyl)-2-methoxy-4-amino-5-bromobenzamide
  • Emoril
  • Emepride
  • Bromoprida
  • Benzamide, 4-amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxy-
  • Artomey
  • 4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
  • 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-o-anisamid
  • 4-amino-5-bromo-n-(2-(diethylamino)ethyl)-2-methoxy-benzamid
  • 4-azanyl-5-bromo-N-(2-diethylaminoethyl)-2-methoxy-benzamide
  • Praiden
  • Plesium
  • Opridan
  • 2-Methoxy-4-aMino-5-broMo-N,N-diethylaMinoethylbenzaMide
  • BROMOPRID
  • 4-Amino-5-bromo-N-[2-(diethylamino)ethyl]-2-methoxybenzamide,Emepride,Emoril,Viadil
  • BROMOPRIDE

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