Uses
Dibutyl disulfide (DBDS) forms the oil phase dispersed as droplets in a synthetic aqueous caustic oil-in-water emulsion that is separated by nanobubble flotation[3]. Di-n-butyl disulfide serves as the disulfide partner in nickel-catalyzed thiolation of aryl iodides, reacting with aryl iodides in DMF at 110 °C under NiBr2-bpy and zinc to give aryl n-butyl sulfides, including the coupling with 2-iodotoluene to n-butyl 2-tolyl sulfide in 76% yield[1]. Dibutyl disulfide acts as the model disulfide in a UV-induced disulfide formation reaction, immobilizing hydrophobic butyl groups on a thiol-functionalized film and raising the static water contact angle from 54° to 118°. Surface modification with dibutyl disulfide under a moving photomask produces a wettability gradient on the thiol-functionalized surface[2].
References
[1]
Taniguchi, N. (2004). Alkyl- or Arylthiolation of Aryl Iodide via Cleavage of the S−S Bond of Disulfide Compound by Nickel Catalyst and Zinc. The Journal of Organic Chemistry, 69(20), 6904–6906.
https://doi.org/10.1021/jo040184q [2]
Li, L., Feng, W., Welle, A., Levkin, P. A. (2016). UV‐Induced Disulfide Formation and Reduction for Dynamic Photopatterning. Angewandte Chemie, 128(44), 13969–13973.
https://doi.org/10.1002/ange.201607276 [3]
Niazmehr, F., Moghbeli, M., Assareh, M., Pourkarimi, Z. (2025). Experimental analysis of nanobubbles for efficient separation of dibutyl disulfide from aqueous caustic waste emulsions. Brazilian Journal of Chemical Engineering, 43(3), 1417–1432.
https://doi.org/10.1007/s43153-025-00600-0
