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Seratrodast

CAS No.112665-43-7
Chemical Name:Seratrodast
CBNumber:CB8284400
Molecular Formula:C22H26O4
Formula Weight:354.44
MOL File:112665-43-7.mol

Seratrodast Property

Melting point 118-120°C
Boiling point 522.3±49.0 °C(Predicted)
Density 1.140±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Yellow-orange solid.
pka 4.76±0.10(Predicted)
color Pale Orange to Yellow
Merck 14,8459
CAS DataBase Reference 112665-43-7(CAS DataBase Reference)
FDA UNII 4U58JM421N
ATC code R03DX06
UNSPSC Code 51111800
NACRES NA.77

Safety

RTECS :DA1600050
HS Code :2918.30.3000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H361
Precautionary statements P201-P202-P280-P308+P313-P405-P501

Seratrodast Price More Price(2)

Brand: TCI Chemicals (India)
Product number: S0943
Product name : Seratrodast
Purity:
Packaging: 100MG
Price: ₹5700
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: S0943
Product name : Seratrodast
Purity:
Packaging: 1G
Price: ₹9800
Updated: 2022/05/26
Buy: Buy

Seratrodast Chemical Properties,Usage,Production

Description Seratrodast, a novel benzoquinone derivative, is the first thromboxane A₂ (TxA₂) receptor antagonist to reach the market. It is orally active for the treatment of bronchospastic disorders such as asthma. TxA₂, a metabolite of the arachidonate cascade, is involved in several cardiovascular and respiratory diseases through its potent biological effects on platelet aggregation and constriction of vascular and respiratory smooth muscles. Seratrodast potently inhibits platelet aggregation and bronchoconstriction induced by a TxA₂ mimic and by a variety of spasmogenic prostanoids including PGF_2α, PGD₂ and 9α,11β-PGF₂. Seratrodast shows excellent efficacy in asthma and has been reported to be potentially useful in hyper-responsive disorder. The R-(+)- seratrodast was reported to be the active isomer.
Chemical Properties Pale Orange Solid
Originator Takeda (Japan)
Uses Thromboxane A2-receptor antagonist. Antiasthmatic.
Uses antibacterial
Definition ChEBI: Seratrodast is an organic molecular entity.
brand name Bronica
Biological Activity Thromboxane A 2 (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA 2 mimetic in guinea pigs.
in vitro seratrodast was found to inhibit the aggregation of guinea pig platelets induced by a prostaglandin endoperoxide analogue, u-44069 and the specific binding of another analogue, [3h]u-46619 to washed guinea pig platelets. seratrodast could competitively inhibit the contraction of rabbit aorta and pig coronary arteries induced by u-44069. seratrodast also inhibited the contraction of rabbit aorta induced by pgf2 alpha and the contraction of pig coronary arteries. however, seratrodast had no effect on the antiaggregatory effect of guinea pig platelets [1].
in vivo in experiments with guinea pigs, oral seratrodast at 0.1-1 mg/kg could dose-dependently inhibit the platelet aggregation induced by u-44069; the inhibition at 1 mg/kg was 100% at 1 hr and was 89% even at 24 hr after seratrodast administration [1].
IC 50 7.4 nm for guinea pig platelets
References [1] imura, y. ,terashita, z.,shibouta, y., et al. antagonistic action of aa-2414 on thromboxane a2/prostaglandin endoperoxide receptor in platelets and blood vessels. japanese journal of pharmacology 52(1), 35-53 (1990).