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CYCLO(-HIS-PRO)

CYCLO(-HIS-PRO) Structure
CYCLO(-HIS-PRO)
  • CAS No.53109-32-3
  • Chemical Name:CYCLO(-HIS-PRO)
  • CBNumber:CB8279260
  • Molecular Formula:C11H14N4O2
  • Formula Weight:234.25
  • MOL File:53109-32-3.mol
CYCLO(-HIS-PRO) Property
  • Melting point 162-164 °C
  • Boiling point 659.3±48.0 °C(Predicted)
  • Density 1.41±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 1 mg/ml
  • form A neat oil
  • pka 12.73±0.40(Predicted)
  • color Light yellow to yellow
  • FDA UNII Q10817UXVT
  • UNSPSC Code 12352209
  • NACRES NA.26
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

CYCLO(-HIS-PRO) Chemical Properties,Usage,Production

  • Uses Cyclo(L-histidyl-L-proline) is used in the pharmaceutical composition comprising cyclo(His-Pro) for preventing or treating obesity.
  • Definition ChEBI: Cyclo(L-His-L-Pro) is a homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). It has a role as a human blood serum metabolite, a dopamine uptake inhibitor and an anti-inflammatory agent. It is a homodetic cyclic peptide, a dipeptide, a pyrrolopyrazine and a member of imidazoles. It is functionally related to a L-histidine and a L-proline.
  • in vivo

    Cyclo(his-pro) (Cyclo(histidyl-proline); 1.8 mg/ear; topical application on the right ear; 30 min prior to TPA) reduces TPA-induced ear oedema confirming that it can exert anti-inflammatory effect[2].
    Cyclo(his-pro) exerts in vivo anti-inflammatory effects in the central nervous system by down-regulating hepatic and cerebral TNFα expression thereby counteracting LPS-induced gliosis. Moreover, by up-regulating Bip, Cyclo(his-pro) increases the ER stress sensitivity andtriggers the unfolded protein response to alleviate the ER stress[3].

    Animal Model:Sixty two/three month-old male C57BL/6 mice (25-30 g)[2]
    Dosage:1.8 mg/ear
    Administration:Topical application on the right ear; 30 min prior to TPA
    Result:Reduced TPA-induced ear oedema.
  • IC 50 NF-κB; Human Endogenous Metabolite
CYCLO(-HIS-PRO) Preparation Products And Raw materials
Raw materials
Preparation Products
CYCLO(-HIS-PRO) Suppliers
Global(94)Suppliers
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    Moxin Chemicals
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CYCLO(-HIS-PRO) Spectrum
53109-32-3, CYCLO(-HIS-PRO)Related Search:
  • 环二肽
  • 高端化学
  • 目录肽
  • 抑制剂
  • 标准品
  • 多肽中间体
  • 氨基酸中间体
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • TRH
  • Releasing Factors
  • Peptides
  • 环(L-HIS-L-PRO)
  • 普罗瑞林EP杂质E
  • (3S,8AS)-3-[(4-咪唑基)甲基]六氢吡咯并[1,2-A]吡嗪-1,4-二酮
  • CYCLO(HIS-PRO) (CYCLO(HISTIDYL-PROLINE))
  • 化合物CYCLO(HIS-PRO)
  • (3S,8AS)-六氢-3-(1H-咪唑-4-基甲基)吡咯并[1,2-A]吡嗪-1,4-二酮
  • 环(组氨酰-脯氨酰)
  • 53109-32-3
  • Nebivolol Impurity 10 Monomer
  • Vitamin B6 Impurity 93
  • Cyclo(Pro-His)
  • (3S,8aS)-3-[(4-Imidazolyl)methyl]hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(HP)
  • Endogenous Metabolite,active,orally,inflammatory,inhibit,tyreotropin-releasing,stress,NF-κB,Cyclo(his-pro),hormone,Nuclear factor-κB,cyclic,Cyclo(hispro),Histidylproline diketopiperazine,Cyclo(histidyl-proline),dipeptide,Cyclo(his pro),Inhibitor,Nuclear factor-kappaB,responses
  • Cyclo(his-pro) (Cyclo(histidyl-proline))
  • (3S,8aS)-3-(1H-Imidazol-4-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-histidyl-L-proline)
  • 3-(1H-imidazol-5-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Protirelin EP Impurity E
  • Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-imidazol-4-ylmethyl)-, (3S,8aS)-
  • Cyclo(his-pro),Cyclo(histidyl-proline),Histidylproline diketopiperazine, >99%
  • CYCLO(HIS-PRO), >99%
  • CYCLO(HISTIDYL-PROLINE); HISTIDYLPROLINE DIKETOPIPERAZINE
  • Cyclo(histidyl-proline)
  • CYCLO(-HIS-PRO)
  • HIS-PRO, CYCLIC
  • Cyclo-Pro-His-HO
  • histidylproline dioxopiperazine
  • Histidylproline diketopiperazine
  • (3S,6S)-3-(3H-imidazol-4-ylmethyl)-1,4-diazabicyclo[4.4.0]decane-2,5-dione

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