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TH287

TH287 Structure
TH287
TH287 Property
  • Boiling point 512.2±60.0 °C(Predicted)
  • Density 1.440±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: soluble5mg/mL, clear (warmed)
  • form powder
  • pka 5.91±0.10(Predicted)
  • color white to beige
  • FDA UNII R6DCB5MSM2
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22-41
  • Safety Statements  :26-39
  • WGK Germany  :3
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H302-H318
  • Precautionary statements P280-P301+P312+P330-P305+P351+P338+P310
TH287 Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1069
  • Product name : TH287 hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹14130.3
  • Updated: 2022/06/14
  • Buy: Buy

TH287 Chemical Properties,Usage,Production

  • Description Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).
  • Uses 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.
  • References 1. gad h, koolmeister t, jemth as et al. mth1 inhibition eradicates cancer by preventing sanitation of the dntp pool. nature. 2014 apr 10;508(7495):215-21.
TH287 Preparation Products And Raw materials
Raw materials
Preparation Products
TH287 Suppliers
Global(106)Suppliers
  • Supplier：
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  • Supplier：
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  • Email：cbc@coresyn.com
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TH287 Spectrum
1609960-30-6, TH287Related Search:
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  • 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
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