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Diphenylphosphinic Chloride

CAS No.1499-21-4
Chemical Name:Diphenylphosphinic Chloride
CBNumber:CB8273899
Molecular Formula:C12H10ClOP
Formula Weight:236.63
MOL File:1499-21-4.mol

Diphenylphosphinic Chloride Property

Melting point 20°C
Boiling point 222 °C/16 mmHg (lit.)
Density 1.24 g/mL at 25 °C (lit.)
refractive index n20/D 1.609(lit.)
Flash point 79 °F
storage temp. 2-8°C
solubility soluble in Chloroform, methanol
form Liquid
Specific Gravity 1.24
color Clear colorless to yellow
Water Solubility decomposes
Sensitive Moisture Sensitive
BRN 975191
CAS DataBase Reference 1499-21-4(CAS DataBase Reference)
FDA UNII 5GP30GY04V
NIST Chemistry Reference Diphenylphosphinic chloride(1499-21-4)
UNSPSC Code 12352002
NACRES NA.22

Safety

Hazard Codes :C,F
Risk Statements :10-34
Safety Statements :16-26-36/37/39-45
RIDADR :UN 2920 8/PG 2
WGK Germany :3
F :10-21
Hazard Note :Flammable/Corrosive
HazardClass :8
PackingGroup :II
HS Code :29310095

NFPA 704:

	2
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H226-H314
Precautionary statements P210-P280-P303+P361+P353-P305+P351+P338+P310

Diphenylphosphinic Chloride Price More Price(9)

Brand: Sigma-Aldrich
Product number: 230235
Product name : Diphenylphosphinic chloride
Purity: 98%
Packaging: 10G
Price: ₹3897
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 230235
Product name : Diphenylphosphinic chloride
Purity: 98%
Packaging: 10G
Price: ₹3897
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 230235
Product name : Diphenylphosphinic chloride
Purity: 98%
Packaging: 50G
Price: ₹15360.68
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 230235
Product name : Diphenylphosphinic chloride
Purity: 98%
Packaging: 50G
Price: ₹15360.68
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-A11721-22
Product name : Diphenylphosphinic chloride, 97+%
Purity:
Packaging: 100g
Price: ₹28299
Updated: 2022/05/26
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Diphenylphosphinic Chloride Chemical Properties,Usage,Production

Chemical Properties clear colorless to yellow liquid
Uses Diphenylphosphinic chloride (Ph₂POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.
Application Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.
reaction suitability reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
Synthesis To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.