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2-VALERYLOXYBENZOIC ACID

CAS No.64206-54-8
Chemical Name:2-VALERYLOXYBENZOIC ACID
CBNumber:CB8270272
Molecular Formula:C12H14O4
Formula Weight:222.24
MOL File:64206-54-8.mol

2-VALERYLOXYBENZOIC ACID Property

Melting point 86-87 °C(lit.)
Boiling point 357.6±25.0 °C(Predicted)
Density 1.175±0.06 g/cm3(Predicted)
storage temp. Room temperature
solubility DMSO: 24 mL/mL
pka 3.01±0.36(Predicted)
form A crystalline solid
color white
UNSPSC Code 12352200
NACRES NA.77

Safety

Safety Statements :22-24/25
WGK Germany :3

NFPA 704:

	0
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P330-P501

2-VALERYLOXYBENZOIC ACID Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: V2889
Product name : Valeryl Salicylate
Purity: ≥98% (HPLC)
Packaging: 100MG
Price: ₹11290.48
Updated: 2022/06/14
Buy: Buy

2-VALERYLOXYBENZOIC ACID Chemical Properties,Usage,Production

Uses Valeryl salicylate is a selective inhibitor of Cox-1.
Definition ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.
Biological Activity valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].

in vivo

Valeryl salicylate (3, 10, 30 mg/kg; i.p.) shows anti-inflammatory effect in arachidonic acid (HY-109590)-induced ear oedema and Carrageenan (HY-125474)-induced paw oedema^[1].

Animal Model:	25-30g, Swiss male mice (arachidonic acid induces Ear oedema)^[1]
Dosage:	1.5, 4.5, 15, 45 μg per ear
Administration:
Result:	Showed the anti-inflammatory effect of topical administration and resulted in significant inhibition of the ear oedema of28, 36, 40, and 58% at 1.5, 4.5, 15, 45 μg per ear.

Animal Model:	25-30g, Swiss male mice (Carrageenan-induced paw oedema)^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	I.p.
Result:	Promoted a significant inhibition of 43.3, 53.3 and 66.6% at 3, 10, 30 mg/kg, respectively.

IC 50 COX-1
References [1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.