17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide

Description

Prostaglandin F_2α (PGF_2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF_2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF_2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF_2α ethyl amide. 17-phenyl trinor PGF_2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF_2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF_2α. Amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.

Uses

N-Cyclopropyl Methyl Bimatoprostis a useful reagent for developing methods for treating epithelial-related conditions including hair loss. N-Cyclopropyl Methyl Bimatoprostis also an analog ofBimatoprost (B386800), an synthetic prostamide and structurally related to prostaglandin F2α.

References

[1] CARL B. CAMRAS MD , PHD  Edward M B M  Nehal Patel MD, PHD , et al. Detection of the free acid of bimatoprost in aqueous humor samples from human eyes treated with bimatoprost before cataract surgery[J]. Ophthalmology, 2004, 111 12: Pages 2193-2198. DOI: 10.1016/j.ophtha.2004.06.028