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Pramipexole Impurity 16

Pramipexole Impurity 16 Structure
Pramipexole Impurity 16
  • CAS No.104632-27-1
  • Chemical Name:Pramipexole Impurity 16
  • CBNumber:CB82449027
  • Molecular Formula:C10H18ClN3S
  • Formula Weight:247.79
  • MOL File:104632-27-1.mol
Pramipexole Impurity 16 Property
  • storage temp. -20°C
  • solubility H2O: >15mg/mL
  • form powder
  • color white to beige
  • optical activity [α]/D 60 to 70°, c = 1 in methanol
  • FDA UNII I9038PKO43
  • UNSPSC Code 41116107
  • NACRES NA.24
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26
  • WGK Germany  :3
  • HS Code  :2934200000
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P301+P312+P330
Pramipexole Impurity 16 Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0392
  • Product name : Dexpramipexole dihydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹15403.98
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0392
  • Product name : Dexpramipexole dihydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹62633.45
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR1824
  • Product name : Pramipexole Related Compound D
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging: 50MG
  • Price: ₹75764.18
  • Updated: 2022/06/14
  • Buy: Buy

Pramipexole Impurity 16 Chemical Properties,Usage,Production

  • Description Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist. For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis. This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.
  • Uses (R)-Pramipexole Dihydrochloride (Pramipexole EP Impurity D; Pramipexole BP Impurity D; Pramipexole USP Related Compound D) is the opposite enantiomer of Pramipexole (P700755), a dopamine-D2-receptor agonist. Dexpramipexole is a low-molecular-weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics.
  • Uses These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Pramipexole may be used as a secondary pharma standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and ultraviolet spectrophotometry technique.
  • General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pramipexole Related Compound D is a pharmaceutical impurity of pramipexole. Pramipexole is a non-ergot dopamine receptor agonist, widely used in the treatment of Parkinson′s disease.
  • Biochem/physiol Actions R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.
Pramipexole Impurity 16 Preparation Products And Raw materials
Raw materials
Preparation Products
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Pramipexole Impurity 16 Spectrum
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  • 104632-27-1
  • Dexpramipexole dihydrochloride, 10 mM in DMSO
  • Pramipexole Impurity D (R-Isomer)
  • Pramipexole EP Impurity D HCl
  • Pramipexole BP Impurity D
  • Glycerol Impurity 41((R)-3-chloropropane-1,2-diol)
  • Dexpramipexole 2HCl
  • Pramipexole Impurity 4 Dihydrochloride（Pramipexole EP Impurity D Dihydrochloride）
  • Dopamine Receptor,inhibit,Inhibitor,KNS-760704,Dexpramipexole,Dexpramipexole dihydrochloride,(R)-Pramipexole,KNS760704,KNS 760704
  • Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride
  • Pramipexole Related Compound D ((R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydro (1553815)
  • Pramipexole EP Impurity D ((R)-Pramipexole diHCl)
  • Dexpramipexole HCl
  • (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
  • KNS-760704 dihydrochloride
  • Pramipexole impurity D CRS
  • Dexpramipexole dihydrochloride ((R)-Pramipexole
  • (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine,dihydrochloride
  • Pramipexole EP Impurity D DiHCl
  • Pramipexole R-Isomer
  • (R)-PRAMIPEXOLE DIHYDROCHLORIDE; KNS 760704; SND 919CL2X
  • Pramipexole dihydrochloride impurity IV
  • Pramipexole Dihydrochloride Hydrate IMP
  • (R)-Pramipexole (hydrochloride)
  • Pramipexole Dihydrochloride Hydrate Impurity
  • RPPX
  • (R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride
  • (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride
  • PraMipexole IMpurity D
  • DexpraMipexole (dihydrochloride)
  • Snd 919cl2x
  • Kns 760704
  • 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (R)-

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