ChemicalBook > CAS DataBase List > 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester

2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester

2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Property

Melting point 222-224 °C
Boiling point 501.1±50.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Powder
pka 4.47±0.40(Predicted)
color White to off-white

Hazard and Precautionary Statements (GHS)

2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Chemical Properties,Usage,Production

Description An Alstonia alkaloid obtained from A. scholaris R. Br., this base also occurs in Rauwolfia vornitora. It has [α]_D - 47° (CHCI3). The ultraviolet spectrum in neutral solution (EtOH) has absorption maxima at 237 and 287 mil, while in acidic solution (perchloric acid), there are absorption maxima at 239, 244 and 305 mil. A methoxycarbonyl group, an alkyl group and an ether bridge are present in the molecule. The picrate is obtained as light yellow crystals with m.p. 172- 4°C (dec.) and the methiodide has m.p. 235-7°C.
Uses Picrinine is a monoterpenoid indole alkaloid extracted from Ochrosia elliptica, displaing the enhancement of immunomodulatory activity and apaptosis inducing in the A549 cell lines.
IC 50 5-Lipoxygenase
References Preparation:
Britten, Smith.,J. Chern. Soc., 3850 (1963)
Isolation:
Chatterjee et al., Tetrahedron Lett., 3633 (1965)

2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Preparation Products And Raw materials

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2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester Spectrum

4684-32-6, 2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl esterRelated Search:

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4684-32-6
methyl (2alpha,5alpha,19E)-1,2-dihydro-2,5-epoxyakuammilan-1...
2H,12H-6,12a-Epoxy-2,7a-methanoindolo[2,3-a]quinolizine-14-carboxylic acid, 3-ethylidene-1,3,4,6,7,12b-hexahydro-, methyl ester, (2R,3E,6S,7aR,12aR,12bS,14R)-
5α-Epoxy-1
2-dihydroakuammilan-17-oic acid methyl ester
Vincaridine
DeacetyldeforMylpicraline
GenericnaMe
Picrinine ,98%
Picrinin
Methyl (2alpha,5alpha,15alpha,16xi,19E)-1,2-dihydro-2,5-epoxyakuammilan-17-oate
Inchi=1/C20H22N2o3/C1-3-11-10-22-15-8-12(11)17(18(23)24-2)19-9-16(22)25-20(15,19)21-14-7-5-4-6-13(14)19/H3-7,12,15-17,21H,8-10H2,1-2H3/B11-3-/T12-,15+,16+,17,19,20+/m1/s
2H,12H-6,12A-Epoxy-2,7A-methanoindolo[2,3-A]quinolizine-14-carboxylic acid, 3-ethylidene-1,3,4,6,7,12B-hexahydro-, methyl ester, (2S,3E,6S,12ar,12bs)-
Picrinine
2α,5α-Epoxy-1,2-dihydroakuammilan-17-oic acid methyl ester