ChemicalBook > CAS DataBase List > Fmoc-Pro-OH

Fmoc-Pro-OH

CAS No.71989-31-6
Chemical Name:Fmoc-Pro-OH
CBNumber:CB8189794
Molecular Formula:C20H19NO4
Formula Weight:337.37
MOL File:71989-31-6.mol

Fmoc-Pro-OH Property

Melting point 117-118 °C(lit.)
alpha -32 º (c=1,DMF)
Boiling point 473.68°C (rough estimate)
Density 1.2486 (rough estimate)
refractive index -32.5 ° (C=1, DMF)
storage temp. Store below +30°C.
solubility Soluble in methanol. (almost transparency.)
pka 3.95±0.20(Predicted)
form Solid
color White to Off-White
optical activity [α]20/D 32±1°, c = 1% in DMF
BRN 3596735
Concentration 0.1 mCi/ml
Solvent Ethanol
Specific Activity 50-60 mCi/mmol
CAS DataBase Reference 71989-31-6(CAS DataBase Reference)
FDA UNII 3HXX85PZ7M
UNSPSC Code 12352209
NACRES NA.26

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-24/25
WGK Germany :3
HS Code :2933 99 80

NFPA 704:

	1
1		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P280-P302+P352-P305+P351+P338

Fmoc-Pro-OH Price More Price(16)

Brand: Sigma-Aldrich(India)
Product number: 8.52017
Product name : Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 25G
Price: ₹2920
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.52017
Product name : Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 100G
Price: ₹4449.99
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.52017
Product name : Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 250G
Price: ₹10330
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 8.52017
Product name : Fmoc-Pro-OH
Purity: Novabiochem?
Packaging: 8520170500
Price: ₹18580
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 47636
Product name : Fmoc-Pro-OH
Purity: ≥99.0% (HPLC)
Packaging: 5G
Price: ₹2987.7
Updated: 2022/06/14
Buy: Buy

Fmoc-Pro-OH Chemical Properties,Usage,Production

Description Fmoc-Pro-OH is easily dissolved in DMF or NMP. Proline fails to produce a blue-to purple color in the Kaiser test. The Isatin test may be used to test the completion of couplings to proline residues.
Chemical Properties white to light yellow crystal powder.
Uses L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
Preparation To a solution of (S)-pyrrolidine-2-carboxylic acid (1 g, 8.7 mmol) in 1,4-dioxane (4 mL) and water (15 mL), K2CO3 (3.24 g, 23 mmol) was added, followed by the addition of 9-fluorenylmethyl chloroformate (2.3 g, 8.3 mmol). The resulting mixture was stirred overnight at room temperature and then treated with water (10 mL). The resulting mixture was extracted with diethyl ether (2 x 20 mL), and the aqueous phase was made acidic with 1M HCl to a pH of 2-3, followed by extraction with dichloromethane (3 x 50 mL). The combined organic layers were dried using anhydrous sodium sulfate and concentrated to yield Fmoc-Pro-OH as a white solid in a 95% yield (2.8 g).
General Description The product number for this product was previously 04-12-1031.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
reaction suitability reaction type: Fmoc solid-phase peptide synthesis