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Triethylenetetramine

CAS No.112-24-3
Chemical Name:Triethylenetetramine
CBNumber:CB8183772
Molecular Formula:C6H18N4
Formula Weight:146.23
MOL File:112-24-3.mol

Triethylenetetramine Property

Melting point 12 °C(lit.)
Boiling point 266-267 °C(lit.)
Density 0.982 g/mL at 25 °C(lit.)
vapor density ~5 (vs air)
vapor pressure <0.01 mm Hg ( 20 °C)
refractive index n20/D 1.496(lit.)
Flash point 290 °F
storage temp. Store below +30°C.
solubility alcohol: soluble
pka pK1:3.32(+4);pK2:6.67(+3);pK3:9.20(+2);pK4:9.92(+1) (20°C)
form Slightly viscous yellow liquid; commercially available form is 95–98% pure, and impurities include linear, branched, and cyclic isomers.
color Yellowish liquid or oil
PH 10-11 (10g/l, H2O, 20℃)
explosive limit 0.7-7.2%(V)
Water Solubility SOLUBLE
FreezingPoint 12℃
Sensitive Moisture Sensitive
Merck 14,9663
BRN 605448
Exposure limits ACGIH: TWA 1 ppm (Skin)
NIOSH: TWA 1 ppm(4 mg/m3)
Stability Incompatible with strong oxidizing agents, strong acids.
LogP -2.65 at 20℃
Indirect Additives used in Food Contact Substances TRIETHYLENETETRAMINE
FDA 21 CFR 175.105; 175.300; 176.170; 176.180; 177.2600
CAS DataBase Reference 112-24-3(CAS DataBase Reference)
EWG's Food Scores 5
FDA UNII SJ76Y07H5F
ATC code A16AX12
NIST Chemistry Reference Triethylenetetramine(112-24-3)
EPA Substance Registry System Triethylenetetramine (112-24-3)
UNSPSC Code 12352116
NACRES NA.22

Safety

Hazard Codes :C
Risk Statements :21-34-43-52/53
Safety Statements :26-36/37/39-45-61
RIDADR :UN 2259 8/PG 2
WGK Germany :2
RTECS :YE6650000
Autoignition Temperature :335 °C
TSCA :Yes
HazardClass :8
PackingGroup :II
HS Code :29212900
Hazardous Substances Data :112-24-3(Hazardous Substances Data)
Toxicity :LD50 orally in rats: 2.5 g/kg (Spitz)

NFPA 704:

	1
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H312-H314-H317-H412
Precautionary statements P261-P272-P273-P280-P303+P361+P353-P305+P351+P338

Triethylenetetramine Price More Price(17)

Brand: Sigma-Aldrich(India)
Product number: 90460
Product name : Triethylenetetramine
Purity: ≥97.0% (T)
Packaging: 10ML
Price: ₹10576.03
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 90460
Product name : Triethylenetetramine
Purity: ≥97.0% (T)
Packaging: 50ML
Price: ₹43397.43
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 132098
Product name : Triethylenetetramine
Purity: technical grade, 60%
Packaging: 100G
Price: ₹3446.33
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 132098
Product name : Triethylenetetramine
Purity: technical grade, 60%
Packaging: 500G
Price: ₹3923.33
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 8.14392
Product name : Triethylenetetramine
Purity: (mixture of isomers) for synthesis
Packaging: 100ML
Price: ₹2140.01
Updated: 2022/06/14
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Triethylenetetramine Chemical Properties,Usage,Production

Description Triethylenetetramine (TETA and trien) also known as trientine (INN) when used medically, is an organic compound with the formula [CH2NHCH2CH2NH2]2. The pure freebase is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air- oxidation. It is soluble in polar solvents. The branched isomer tris(2-aminoethyl)amine and piperazine derivatives may also be present in commercial samples of Triethylenetetramine. The hydrochloride salts are used medically as a treatment for copper toxicity.
Chemical Properties Triethylenetetramine is a corrosive liquid.
Uses Triethylenetetramine is used as an amine hardener in epoxy resin of the bisphenol A type.It is used in synthesis of detergents, softeners, and dyestuffs; manufacture of pharmaceuticals; vulcanization accelerator of rubber; thermo setting resin; epoxy curing agent; lubricating-oil additive; analytical reagent for Cu, Ni; chelating agent; treatment of Wilson's disease.
Production Methods Triethylenetetramine(TETA) is manufactured by reacting ethylene dichloride and ammonia under controlled conditions.
Definition ChEBI: 2,2,2-tetramine is a polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. It has a role as a copper chelator. It is a tetramine and a polyazaalkane.
brand name Syprine (Merck).
General Description A yellowish liquid. Less dense than water. Combustible, though may be difficult to ignite. Corrosive to metals and tissue. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion. Used in detergents and in the synthesis of dyes, pharmaceuticals and other chemicals.
Chemical Properties Triethylenetetramine (TETA) is hygroscopic, corrosive, and has a strong ammoniacal odor. With water a crystalline hydrate is formed. Like DETA, it is completely miscible with water and many polar organic solvents, but less so with lipids; with CCl4 a violent reaction occurs. Its four pKa values are 3.32, 6.67, 9.20, and 9.92. Technical-grade TETA is sometimes available as a distillation cut that also contains branched isomers and cyclic compounds.
Reactivity Profile Triethylenetetramine is a strong base; reacts violently with strong oxidants; attacks aluminum, zinc, copper and its alloys. Handling Chemicals Safely 198. p. 934).
Health Hazard Vapors from hot liquid can irritate eyes and upper respiratory system. Liquid burns eyes and skin. May cause sensitization of skin.
Fire Hazard Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Flammability and Explosibility Non flammable
Contact allergens Triethylenetetramine is used as an amine hardener in epoxy resins of the bisphenol A type. Cross-sensitivity is possible with diethylenetriamine and diethylenediamine.
Safety Profile Poison by intravenous route. Moderately toxic by ingestion and skin contact. An experimental teratogen. Experimental reproductive effects. Mutation data reported. A corrosive irritant to skin, eyes, and mucous membranes. Causes skin sensitization. Combustible when exposed to heat or flame. Ignites on contact with cellulose nitrate of high surface area. Can react with oxidizing materials. To fight fire, use CO2, dry chemical, alcohol foam. When heated to decomposition it emits toxic fumes of NOx.
Toxicology Triethylenetetramine may induce lung edema on inhalation of its vapors. The compound is also an effective skin sensitizer. Following repeated dosing (ca. 50 mg each, 17 – 55 times) onto the skin of pregnant and nonpregnant guinea pigs, significant amounts were absorbed by the strongly irritated skin, leading to toxic effects in the kidneys, liver, brain, and placenta and causing abortion. Triethylenetetramine proved to be a mutagen in vitro but not in vivo.
Carcinogenicity TETA was mutagenic in bacterial assays and was positive in sister chromatid exchanges and unscheduled DNA synthesis tests in vitro.8 It was not clastogenic in the mouse micronucleus test in vivo after oral or intraperitoneal administration.
Purification Methods Dry the amine with sodium, then distil it under a vacuum. Further purification has been via the nitrate or the chloride salts. For example, Jonassen and Strickland [J Am Chem Soc 80 312 1958] separated TRIEN from admixture with TREN (38%) by solution in EtOH, cooling to approximately 5o in an ice-bath and adding conc HCl dropwise from a burette, keeping the temperature below 10o, until all of the white crystalline precipitate of TREN.HCl (see p 191) had formed and was removed. Further addition of HCl then precipitated thick, creamy white TRIEN.HCl (see below) which was crystallised several times from hot water by adding an excess of cold EtOH. The crystals were finally washed with Me2CO, then Et2O and dried in a vacuum desiccator. [Beilstein 4 H 255, 4 II 695, 4 III 542, 4 IV 1242.]
Toxics Screening Level The initial threshold screening level (ITSL) for triethylene tetramine (TETA) is 8 μg/m 3 based on annual averaging time.