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Diethylenetriaminepentaacetic acid

CAS No.67-43-6
Chemical Name:Diethylenetriaminepentaacetic acid
CBNumber:CB5303977
Molecular Formula:C14H23N3O10
Formula Weight:393.35
MOL File:67-43-6.mol

Diethylenetriaminepentaacetic acid Property

Melting point 219-220 °C (lit.)
Boiling point 517.84°C (rough estimate)
Density 1.56
bulk density 580kg/m3
refractive index 1.5700 (estimate)
Flash point 200 °C
storage temp. room temp
solubility 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
form Crystalline Powder
color White to almost white
PH 2-3 (H2O, 20℃)(saturated solution)
biological source synthetic (organic)
Water Solubility 5 g/L (20 ºC)
Merck 14,7125
BRN 1810219
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey QPCDCPDFJACHGM-UHFFFAOYSA-N
LogP -1.361 (est)
CAS DataBase Reference 67-43-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 7A314HQM0I
NIST Chemistry Reference N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
EPA Substance Registry System Pentetic acid (67-43-6)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xi,N,Xn
Risk Statements :36-51/53-36/37/38-20-63
Safety Statements :26-36-61-37/39-36/37
RIDADR :UN 3077 9/PG 3
WGK Germany :2
RTECS :MB8205000
F :3
TSCA :Yes
HazardClass :9
PackingGroup :III
HS Code :29224995
Toxicity :LD50 orally in Rabbit: > 2000 mg/kg

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319-H332-H361fd-H373
Precautionary statements P201-P202-P260-P304+P340+P312-P305+P351+P338-P308+P313

Diethylenetriaminepentaacetic acid Price More Price(26)

Brand: Sigma-Aldrich(India)
Product number: D6518
Product name : Diethylenetriaminepentaacetic acid
Purity: ≥99% (titration)
Packaging: 10G
Price: ₹7501.73
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: D6518
Product name : Diethylenetriaminepentaacetic acid
Purity: ≥99% (titration)
Packaging: 5G
Price: ₹7880.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR2645
Product name : Pentetic Acid
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 200MG
Price: ₹15858.63
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: D6518
Product name : Diethylenetriaminepentaacetic acid
Purity: ≥99% (titration)
Packaging: 50G
Price: ₹22451.05
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D6518
Product name : Diethylenetriaminepentaacetic acid
Purity: ≥99% (titration)
Packaging: 100G
Price: ₹32128.6
Updated: 2022/06/14
Buy: Buy

Diethylenetriaminepentaacetic acid Chemical Properties,Usage,Production

Chemical Properties Pentetic acid occurs as a white crystalline solid and is almost odorless.
Chemical Properties Diethylenetriaminepentaacetic acid is a solid.
Uses chelating agent, diagnostic aid
Uses Diethylenetriaminepentaacetic acid is used as chelating agent and forms complexes with metal ions. It finds application as a magnetic resonance imaging (MRI) contrasting agent, since it improves the image by forming a complex with a gadolinium ion. It can also be used for treatment of radioactive materials such as plutonium, americium and other actinides. It is an active component of manganese and zinc fertilizers used in agrochemical industry. It acts as a color inhibitor and is used in the production of acrylon. It is also used in soaps as a water softener.
Uses Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
Definition ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-).
Production Methods Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.
General Description Visit our Titration Center to learn more.
reaction suitability reaction type: Complexometric reactions
Pharmaceutical Applications Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.
Safety Profile Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Safety Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD₅₀ (mouse, IP): 0.54 g/kg
LD₅₀ (mouse, oral): 4.84 g/kg
storage The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Purification Methods Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
Incompatibilities The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Regulatory Status Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.