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4-Chlororesorcinol

CAS No.95-88-5
Chemical Name:4-Chlororesorcinol
CBNumber:CB8131955
Molecular Formula:C6H5ClO2
Formula Weight:144.56
MOL File:95-88-5.mol

4-Chlororesorcinol Property

Melting point 106-108 °C (lit.)
Boiling point 147 °C/18 mmHg (lit.)
Density 1.2558 (rough estimate)
vapor pressure 0.16Pa at 25℃
refractive index 1.4620 (estimate)
Flash point 146-148°C/18mm
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility >1000g/l
pka 8.28±0.10(Predicted)
form Powder
color Beige
PH 3.8 (10g/l, H2O, 30℃)
Water Solubility soluble
BRN 2042864
Stability Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents.
LogP 0.895 at 25℃
CAS DataBase Reference 95-88-5(CAS DataBase Reference)
EWG's Food Scores 3-6
FDA UNII 87045U29QJ
NIST Chemistry Reference 1,3-Benzenediol, 4-chloro-(95-88-5)
EPA Substance Registry System 4-Chlororesorcinol (95-88-5)
UNSPSC Code 41116107
NACRES NA.22

Safety

Hazard Codes :Xn
Risk Statements :20/21/22-36/37/38-22
Safety Statements :26-36-22
WGK Germany :3
RTECS :VH0450000
TSCA :Yes
HS Code :29081000

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H302-H315-H317-H318-H412
Precautionary statements P261-P273-P280-P301+P312-P302+P352-P305+P351+P338

4-Chlororesorcinol Price More Price(9)

Brand: Sigma-Aldrich(India)
Product number: C70606
Product name : 4-Chlororesorcinol
Purity: 98%
Packaging: 100G
Price: ₹3745.45
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: C70606
Product name : 4-Chlororesorcinol
Purity: 98%
Packaging: 500G
Price: ₹14159.1
Updated: 2022/06/14
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Brand: ALFA India
Product number: ALF-B24076-36
Product name : 4-Chlororesorcinol, 98%
Purity:
Packaging: 500g
Price: ₹11480
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-B24076-22
Product name : 4-Chlororesorcinol, 98%
Purity:
Packaging: 100g
Price: ₹3116
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-B24076-14
Product name : 4-Chlororesorcinol, 98%
Purity:
Packaging: 25g
Price: ₹1248
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4-Chlororesorcinol Chemical Properties,Usage,Production

Chemical Properties 4-Chlororesorcinol is a colorless crystals or off-white to light brown powder. The melting point is 89°C (106.5-107.5°C), the boiling point is 259°C, 147°C (2.4kPa). Soluble in water, alcohol, ether, benzene and carbon disulfide. Can sublimate. It reacts with ferric chloride to generate blue-purple.
Uses 4-Chlororesorcinol, can be used as hair dye formulation. It can also be used in the synthesis of series of six coumarin compounds carrying halogen and trifluoromethyl, having antifungal activities.
Application In cosmetics and personal care products, 4-Chlororesorcinol is used in the formulation of hair dyes, colors and tints.
4-Chlororesorcinol is used in permanent hair coloring systems where color is produced inside the hair fiber. This is accomplished through careful formulation of the product so that the ingredients interact in a highly controlled process.
Preparation 4-Chlororesorcinol is synthesized by reacting resorcinol with dichlorosulfuryl. Resorcinol and diethyl ether were mixed, heated to reflux with stirring, and dichlorosulfuryl was slowly added dropwise. The temperature was then raised to 60°C for 1 h. After recovery of ether, atmospheric distillation is carried out, the distillate is subjected to vacuum distillation again, and the 131°C (0.8-0.93kPa) or 160-164°C (4.0kPa) fractions are collected to obtain the finished 4-chlororesorcinol.
Flammability and Explosibility Non flammable
Safety 4-chlororesorcinol is classified as a toxic substance and exposure to high concentration of 4-chlororesorcinol could cause several health issues including, skin irritation, serious eye irritation, and other hazards.
The safety of 4-Chlororesorcinol has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that 4-Chlororesorcinol was safe in hair dye formulations.
The CIR Expert Panel concluded that the scientific data suggested that 4-Chlororesorcinol can be safely used in hair dye products. Subchronic dermal exposure to a hair dye product containing 2% 4-Chlororesorcinol produced no evidence of compound-induced toxicity. At the same concentration, no development effects, no evidence of reproductive toxicity, and no carcinogenic effects were seen following dermal exposure. Likewise, 4-Chlororesorcinol was not mutagenic in either a micronucleus or in bacteria, nor did it induce aneuploidy in fungus cells. A 2.5% solution was not a dermal irritant or an ocular irritant.
Purification Methods Crystallise it from boiling CCl4 (10g/L, charcoal) and dry it in air. [Beilstein 6 II 818.] IRRITANT.