Synthesis
Methyl 3-Z-iodoacrylate was converted to methyl (E)-3-iodoacrylate by hydriodic acid-catalyzed isomerization reaction in benzene (24,25) using methyl (Z)-3-iodoacrylate as a raw material. The reaction also produced the by-product methyl 3-pentyl-1-iodoacrylate 13 in 85% yield (Scheme 3).
References
[1] Tetrahedron, 2009, vol. 65, # 40, p. 8418 - 8427
[2] Patent: WO2012/76842, 2012, A1. Location in patent: Page/Page column 33-34
[3] European Journal of Organic Chemistry, 2016, vol. 2016, # 12, p. 2110 - 2114
[4] Organic Letters, 2015, vol. 17, # 3, p. 520 - 523
[5] Patent: WO2015/119899, 2015, A1. Location in patent: Page/Page column 110
