ChemicalBook > CAS DataBase List > Anileridine
Anileridine
- CAS No.144-14-9
- Chemical Name:Anileridine
- CBNumber:CB81178032
- Molecular Formula:C22H28N2O2
- Formula Weight:352.47
- MOL File:144-14-9.mol
Anileridine Property
- Melting point 83°C
- Boiling point 486.07°C (rough estimate)
- Density 1.1096 (rough estimate)
- refractive index 1.6500 (estimate)
- solubility DMSO (Slightly), Ethyl Acetate (Soluble)
- pka 8.41±0.10(Predicted)
- form Solid
- FDA UNII 71Q1A3O279
Safety
- RIDADR :1544
- HazardClass :6.1(b)
- PackingGroup :III
- Hazardous Substances Data :144-14-9(Hazardous Substances Data)
- Toxicity :LD50 orl-rat: 175 mg/kg 27ZIAQ -,-,65
- Symbol(GHS)
- Signal word
- Hazard statements
- Precautionary statements
Anileridine Chemical Properties,Usage,Production
- Originator Leritine HCl,Merck Sharp and Dohme,US,1958
- Uses A synthetic analgesic drug. 4-phenylpiperidine derivative that is an analog of Meperidine (M223900) with increased analgesic activity.
- Definition ChEBI: A piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl) thyl group.
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Manufacturing Process
A mixture of 7.8 grams (0.05 mol) of β-(p-aminophenyl)ethyl chloride
hydrochloride, 12.5 grams (0.025 mol) of 4-phenyl-4-carboethoxypiperidine
carbonate, 10.5 grams (0.125 mol) sodium bicarbonate, and 100 cc of
anhydrous ethanol are mixed, stirred and heated under reflux for a period of
approximately 40 hours and then concentrated in vacuum to dryness. The
residual material is triturated with 50 cc of water, decanted, washed by
decantation with an additional 50 cc of water, and then dried in vacuum to
give N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine.
The N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine is dissolved in 50 cc of hot anhydrous ethanol, an excess (about 20 cc) of 20% alcoholic hydrochloric acid solution is added; upon scratching the side of the container crystals form. One hundred cubic centimeters of ether are then added to the mixture, the ethereal mixture is cooled, and the crystalline material which precipitates is recovered by filtration, washed with ether, and dried to give 12.7 grams of N-[β-(p-aminophenyl)ethyl]-4-phenyl-4-carboethoxypiperidine dihydrochloride which can be further purified by recrystallization from ethanol or methanal to give substantially pure material; MP 275-277°C. - brand name Leritine (Merck).
- Therapeutic Function Narcotic analgesic
- Safety Profile Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.When heated to decomposition it emits toxic fumes ofNOx.
Anileridine Preparation Products And Raw materials
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144-14-9, AnileridineRelated Search:
- CHEMBRDG-BB 4010734 NORMEPERIDINE PETHIDINIC ACID MEPERIDINE 1,4-DIMETHYLPIPERIDINE-4-CARBOXYLIC ACID 4-(2-PIPERIDIN-1-YL-ETHYL)-ANILINE 4-PHENYL-4-PIPERIDINE CARBOXYLIC ACID ETHYL 1,4-DIMETHYLPIPERIDINE-4-CARBOXYLATE 4-(2-DIMETHYLAMINO-ETHYL)-ANILINE 4-Methylisonipecotic acid ethyl ester Anileridine Pheneridine 4-PHENYL-4-PIPERIDINECARBOXALDEHYDE
- Pharmaceuticals
- Neurochemicals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- 144-14-9
- Anileridine (1.0 mg/mL in ethyl acetate)
- 4-Piperidinecarboxylic acid, 1-[2-(4-aminophenyl)ethyl]-4-phenyl-, ethyl ester
- LKYQLAWMNBFNJT-UHFFFAOYSA-N
- Adopol-d4
- 1-[2-(4-AMinophenyl)ethyl]-4-phenyl-4-(piperidinec-d4)arboxylic Acid Ethyl Ester
- 1-(p-AMinophenethyl)-4-phenylisonipecotic Acid-d4 Ethyl Ester
- 1-(p-AMinophenethyl)-4-phenyl(piperidine-d4)-4-carboxylic Acid Ethyl Ester
- Ethyl 1-(4
- Apidol
- Alidine
- Adopol
- 1-[2-(4-AMinophenyl)ethyl]-4-phenyl-4-piperidinecarboxylic Acid Ethyl Ester
- 1-(p-AMinophenethyl)-4-phenylpiperidine-4-carboxylic Acid Ethyl Ester
- 1-(p-AMinophenethyl)-4-phenylisonipecotic Acid Ethyl Ester
- anileridine base
