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METHYLLYCACONITINE CITRATE

METHYLLYCACONITINE CITRATE Structure
METHYLLYCACONITINE CITRATE
  • CAS No.112825-05-5
  • Chemical Name:METHYLLYCACONITINE CITRATE
  • CBNumber:CB8113766
  • Molecular Formula:C43H58N2O17
  • Formula Weight:874.92
  • MOL File:112825-05-5.mol
METHYLLYCACONITINE CITRATE Property
  • storage temp. −20°C
  • solubility H2O: 42 mg/mL
  • form solid
  • color white
  • biological source Delphinium brownii seeds
  • Water Solubility H2O: 42mg/mL
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
METHYLLYCACONITINE CITRATE Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: M168
  • Product name : Methyllycaconitine citrate salt
  • Purity: from Delphinium brownii seeds, ≥96% (HPLC)
  • Packaging: 5MG
  • Price: ₹13433.83
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M168
  • Product name : Methyllycaconitine citrate salt
  • Purity: from Delphinium brownii seeds, ≥96% (HPLC)
  • Packaging: 25MG
  • Price: ₹41102.53
  • Updated: 2022/06/14
  • Buy: Buy

METHYLLYCACONITINE CITRATE Chemical Properties,Usage,Production

  • Uses Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:
    • to study its effects on inflammatory response in rats post nicotine treatment
    • to block the activity of galantamine
    • to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats

  • Biological Activity methyllycaconitine citrate(mla) is an antagonist of α7-containing neuronal nicotinic acetylcholine receptors (nachrs; ki = 1.4 nm)[1,2].mla inhibits the decreased cell viability induced by aβ25-35, pretreatment with 5 and 10 μm. aβ25-35 treatment increases lc3-ii levels, which is inhibited by administration of methyllycaconitine citrate. mla also inhibits aβ-induced autophagosome accumulation in sh-sy5y cells[3].mla inhibits methamphetamine(meth)-induced climbing behavior by 50%. mla prevents a decrease in striatal synaptosome dopamine (da) uptake, mla significantly attenuates meth-induced neurotoxicity at 72 h post-treatment. mla fully prevents microglial activation at 24 h post-treatment and tending to confirm its neuroprotective activity[4].[1]. kalappa b i, sun f, johnson s r, et al. a positive allosteric modulator of α7 nachrs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. brit.j.pharmacol, 2013, 169(8): 1862-1878.[2]. ward j m, cockcroft v b, lunt g g, et al. methyllycaconitine: a selective probe for neuronal α-bungarotoxin binding sites. febs lett, 1990, 270(1-2): 45-48 .[3]. zheng x, et al. methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in sh-sy5y cells. plos one, 2014, 9(10): e111536.[4]. escubedo e, et al. methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. j pharmacol exp ther, 2005, 315(2): 658-67.
  • Biochem/physiol Actions Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium. MLA binds to the binding site of neuronal α-bungarotoxin. Low doses of MLA are associated with improvement of cognition in animals.
METHYLLYCACONITINE CITRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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METHYLLYCACONITINE CITRATE Spectrum
112825-05-5, METHYLLYCACONITINE CITRATERelated Search:
  • 药靶配体
  • 标准品
  • 生化试剂
  • METHYLLYCACONITINE CITRATE (MLA),ALPHA7 NICOTINIC RECEPTOR拮抗剂
  • 甲基牛扁亭柠檬酸盐(MLA)
  • 甲基卡卡尼汀(柠檬酸盐)
  • 甲基牛扁碱柠檬酸盐
  • 重组人INTERLEUKIN-17A/IL-17A蛋白
  • 柠檬酸甲基牛扁碱
  • 112825-05-5
  • Melycaconitine citrate - Bio-X ?
  • Melycaconitine citrate
  • Methyllycaconitine citrate (MLA), alpha7 Nicotinic receptor antagonist
  • Aconitane-7,8-diol, 20-ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]-, [1α,4(S),6β,14α,16β]-, 2-hydroxy-1,2,3-propanetricarboxylate (salt) (9CI)
  • MLA (Methyllycaconitine Citrate)
  • INTERLEUKIN-17A; IL-17; IL-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8; CTLA-8; IL17A; CTLA8; IL17
  • Cytotoxic T-Lymphocyte-Associated Antigen 8
  • Methyllycaconitine citrate salt
  • [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt
  • MLA
  • [1A,4(S),6B,14A,16B]-20-ETHYL-1,6,14,16-TETRAMETHOXY-4-[[[2-(3-METHYL-2,5-DIOXO-1-PYRROLIDINYL)BENZOYL]OXY]METHYL]ACONITANE-7,8-DIOL CITRATE
  • [1ALPHA,4(S),6BETA,14ALPHA,16BETA]-20-ETHYL-1,6,14,16-TETRAMETHOXY-4[[[2-(3-METHYL-2,5-DIOXO-1-PYRROLIDINYL)BENZOYL]OXY]METHYL]-ACONITANE-7,8-DIOL CITRATE
  • METHYLLYCACONITINE CITRATE

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