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Sorbinil

Sorbinil Structure
Sorbinil
  • CAS No.68367-52-2
  • Chemical Name:Sorbinil
  • CBNumber:CB81117527
  • Molecular Formula:C11H9FN2O3
  • Formula Weight:236.2
  • MOL File:68367-52-2.mol
Sorbinil Property
  • Melting point 241-243°
  • alpha D25 +54.0° (c = 1 in methanol)
  • Density 1.52
  • storage temp. 2-8°C
  • solubility DMSO: ≥20mg/mL
  • form powder
  • pka 8.91±0.20(Predicted)
  • color white to off-white
  • optical activity [α]/D +50 to +60°, c = 1 in methanol
  • FDA UNII G4186B906P
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501
Sorbinil Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: S7701
  • Product name : Sorbinil
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹13975.08
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: S7701
  • Product name : Sorbinil
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹55218.33
  • Updated: 2022/06/14
  • Buy: Buy

Sorbinil Chemical Properties,Usage,Production

  • Uses Enzyme inhibitor (aldose reductase).
  • Uses Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.
  • Definition ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.
  • Biochem/physiol Actions Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.
  • in vivo

    Sorbinil (10 mg/kg; ip; single dose ) attenuates LPS-induced uveitis in mice eyes[2].

Sorbinil Preparation Products And Raw materials
Raw materials
Preparation Products
Sorbinil Suppliers
Global(28)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier： Sigma-Aldrich
  • Tel：021-61415566<br/>800-8193336
  • Email：orderCN@merckgroup.com
  • Country：China
  • ProdList：51456
  • Advantage：80
  • Supplier： Shanghai Synchem Pharma Co., ltd
  • Tel：21-619849051-1<br/>18521059765
  • Email：synchempharma@aliyun.com
  • Country：China
  • ProdList：6466
  • Advantage：55
  • Supplier： Energy Chemical
  • Tel：021-58432009<br/>400-005-6266
  • Email：marketing@energy-chemical.com
  • Country：China
  • ProdList：44918
  • Advantage：58
Sorbinil Spectrum
68367-52-2, SorbinilRelated Search:
  • 抑制剂
  • 索比尼尔,10 MM DMSO 溶液
  • 68367-52-2
  • Sorbinil, 10 mM in DMSO
  • inhibit,Aldose Reductase,Sorbinil,Inhibitor
  • Sorbinil >=98% (HPLC)
  • (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione
  • (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione
  • (S)-(+)-Sorbinil
  • (4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
  • CP-45634
  • (S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
  • (4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione
  • (4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
  • Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)-

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