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Ivabradine hydrochloride

Ivabradine hydrochloride Structure
Ivabradine hydrochloride
  • CAS No.148849-67-6
  • Chemical Name:Ivabradine hydrochloride
  • CBNumber:CB81006694
  • Molecular Formula:C27H37ClN2O5
  • Formula Weight:505.05
  • MOL File:148849-67-6.mol
Ivabradine hydrochloride Property
  • Melting point 193-196?C
  • alpha 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
  • storage temp. 2-8°C
  • solubility H2O: ≥5mg/mL (warmed)
  • form powder
  • color white to beige
  • optical activity [α]/D +5 to +9°, c = 1 in DMSO
  • Water Solubility H2O: ≥5mg/mL (warmed)
  • Merck 14,5247
  • InChIKey HLUKNZUABFFNQS-ZMBIFBSDSA-N
  • SMILES C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
  • CAS DataBase Reference 148849-67-6(CAS DataBase Reference)
  • FDA UNII TP19837BZK
  • NCI Drug Dictionary ivabradine hydrochloride
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :N
  • Risk Statements  :50/53
  • Safety Statements  :60-61
  • RIDADR  :UN 3077 9 / PGIII
  • WGK Germany  :3
  • HS Code  :2933.79.1500
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H400
  • Precautionary statements P273
Ivabradine hydrochloride Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0281
  • Product name : Ivabradine hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 10MG
  • Price: ₹9645.08
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0281
  • Product name : Ivabradine hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹37530.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0847
  • Product name : Ivabradine Hydrochloride
  • Purity: 
  • Packaging: 200MG
  • Price: ₹9700
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: I0847
  • Product name : Ivabradine Hydrochloride
  • Purity: 
  • Packaging: 1G
  • Price: ₹25500
  • Updated: 2022/05/26
  • Buy: Buy

Ivabradine hydrochloride Chemical Properties,Usage,Production

  • Description In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .
  • Chemical Properties White to Off-White Solid
  • Originator Servier (France)
  • Uses angina therapeutic
  • Uses Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent
  • Uses Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal
  • Uses Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).
  • Definition ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.
  • brand name Procoralan
  • Biochem/physiol Actions Ivabradine is used to treat chronic heart failure.
  • Clinical Use Symptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm Treatment of mild to severe chronic heart failure
  • storage Store at -20°C
Ivabradine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ivabradine hydrochloride Suppliers
Global(474)Suppliers
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Ivabradine hydrochloride Spectrum
148849-67-6, Ivabradine hydrochlorideRelated Search:
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  • C27H36N2O5HCl
  • C27H37ClN2O5
  • 1448849-67-6
  • 48849-67-6
  • 148849-54-6
  • IVABRADINE HCL 盐酸伊伐布雷定 |CAS 148849-67-6
  • 3-(3-{[((7S)-3,4-二甲氧基双环[4.2.0]辛-1,3,5-三烯-7-基)甲基]甲氨基}丙基)-1,3,4,5-四氢-7,8-二甲氧基-2H-3-苯并氮杂?-2-酮,盐酸盐
  • 盐酸伊伐布雷定,10 MM DMSO 溶液
  • 优选]IVABRADINE HCL
  • (S)-3-(3-(((3,4-二甲氧基双环[4.2.0]辛-1,3,5-二烯-7-基)甲基)(甲基)氨基)丙基)-7,8-二甲氧基-1,3,4,5-四氢-2H-苯并[D]]氮杂卓-2-酮盐酸盐
  • 酸伊伐布雷定
  • 3-[3-[[(8S)-3,4-二甲氧基-8-双环[4.2.0]辛-1,3,5-三烯]甲基-甲氨基]丙基]-7,8-二甲氧基-2,
  • 盐酸伊伐布雷定/盐酸依法布雷定/盐酸依伐布雷定/
  • 盐酸伊伐布雷定 , 一种 IF 抑制剂
  • IVABRADINE HYDROCHLORIDE 盐酸伊伐布雷定
  • 伊伐布雷盐酸盐
  • 伊伐布雷定,盐酸D6
  • IF抑制剂(IVABRADINE HYDROCHLORIDE)
  • 盐酸伊伐布雷定/盐酸依法布雷定
  • 盐酸伊伐布雷
  • 盐酸伊伐布雷定
  • 盐酸依法布雷定
  • 3-[3-[[(8S)-3,4-二甲氧基-8-双环[4.2.0]辛-1,3,5-三烯]甲基-甲氨基]丙基]-7,8-二甲氧基-2,5-二氢-1H-3-苯并氮杂卓-4-酮盐酸盐
  • 伊伐布雷定盐酸盐

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