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phenoperidine

phenoperidine Structure
phenoperidine
  • CAS No.562-26-5
  • Chemical Name:phenoperidine
  • CBNumber:CB7930605
  • Molecular Formula:C23H29NO3
  • Formula Weight:367.48
  • MOL File:562-26-5.mol
phenoperidine Property
  • Boiling point 508.8±50.0 °C(Predicted)
  • Density 1.122±0.06 g/cm3(Predicted)
  • pka 14.31±0.20(Predicted)
  • FDA UNII G9BH09J4JW
  • ATC code N01AH04
Safety
  • RIDADR  :3249
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • DEA Controlled Substances :CSCN: 9641
    CSA SCH: Schedule I
    NARC: Yes
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

phenoperidine Chemical Properties,Usage,Production

  • Originator Operidine ,Janssen ,US ,1965
  • Definition ChEBI: Phenoperidine is a member of piperidines.
  • Manufacturing Process The starting materials for the overall process are phenylacetonitrile with bischloroethyl toluene sulfonyl amide. These react to give a product which hydrolyzes to normeperidine (4-carboethoxy-4-phenylpiperidine). Condensation of that material with benzoylethylene gives the ketone: β-(4carboethoxy-4-phenylpiperidino)propiophenone.
    A reaction mixture was prepared containing 4 grams of β-(4-carboethoxy-4phenylpiperidino)-propiophenone hydrochloride, 100 ml of methanol and about 0.5 gram of platinum oxide catalyst. The mixture was placed in a low pressure hydrogenation apparatus and was hydrogenated at a temperature of about 27°C and a pressure of about 3.5 atmospheres of hydrogen to convert the keto group of the β-(4-carboethoxy-4-phenylpiperidino)-propiophenone to a hydroxy group, and to form 3-(4-carboethoxy-4-phenylpiperidino)-1-phenyl-1propanol hydrochloride. After the hydrogenation was complete, the catalyst was separated from the reaction mixture by filtration, and the filtrate was evaporated to dryness in vacuo leaving a residue containing 3-(4carboethoxy-4-phenylpiperidino)-1-phenyl-l-propanol hydrochloride. The residue was digested with ethyl acetate thereby causing 3-(4-carboethoxy-4phenylpiperidino)-1-phenyl-1-propanol hydrochloride to crystallize. This compound melted at about 188°-189°C after being recrystallized three times from an ethyl acetate-methanol solvent mixture, according to US Patent 2,951,080.
  • Therapeutic Function Analgesic
phenoperidine Preparation Products And Raw materials
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phenoperidine Spectrum
562-26-5, phenoperidineRelated Search:
  • 苯哌利定
  • 562-26-5
  • 4-Piperidinecarboxylic acid, 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-, ethyl ester
  • ethyl 1-(3-hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylate
  • IPOPQVVNCFQFRK-UHFFFAOYSA-N
  • 1-(3-Hydroxy-3-phenylpropyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester
  • phenoperidine

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