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butropium bromide

butropium bromide Structure
butropium bromide
  • CAS No.29025-14-7
  • Chemical Name:butropium bromide
  • CBNumber:CB7877900
  • Molecular Formula:C28H38NO4.Br
  • Formula Weight:532.515
  • MOL File:29025-14-7.mol
butropium bromide Property
  • Melting point 166-168oC
  • alpha D20 -21.7° (c = 0.5 in water)
  • storage temp. Refrigerator
  • solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
  • form Solid
  • color White to Off-White
  • FDA UNII R3K4503MV7
Safety
  • Toxicity :LD50 in male mice (mg/kg): 1500 orally; 660 s.c.; 12.0 i.v. (Tanaka, Hashimoto, 1972)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

butropium bromide Chemical Properties,Usage,Production

  • Chemical Properties Crystalline Solid
  • Originator Coliopan,Eisai,Japan,1974
  • Uses Anticholinergic. Antispasmodic.
  • Definition ChEBI: Butropium bromide is an organic bromide salt of butropium. It is a drug which suppresses spasm of smooth muscles of internal organs, inhibits gastric acid secretion and relieves abdominal pain. It is used in the treatment of spasmodic pains associated with gastritis, gastric ulcers and cholelithiasis. It has a role as an antispasmodic drug and a muscarinic antagonist. It is an organic bromide salt and a quaternary ammonium salt. It contains a butropium.
  • Manufacturing Process To 100 ml of an isopropanol solution containing 11.8 grams of hyoscyamine base were added drop by drop with stirring 10 ml of an isopropanol solution containing 11 grams of p-n-butoxybenzyl bromide. After a while, the reaction mixture had a turbid appearance followed by separation of white crystals.
    After stirring for 5 hours at room temperature, the crystals were recovered by filtration, which were then recrystallized from 120 ml of isopropanol. There was obtained 15.8 grams of white needles having the melting point of 158°- 160°C.
  • Therapeutic Function Spasmolytic
butropium bromide Preparation Products And Raw materials
Raw materials
Preparation Products
butropium bromide Suppliers
Global(16)Suppliers
  • Supplier： J & K SCIENTIFIC LTD.
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  • Supplier： Shaanxi Pioneer Biotech Co., Ltd.
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  • Supplier： Energy Chemical
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butropium bromide Spectrum
29025-14-7, butropium bromideRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • C28H38BrNO4
  • C28H38NO4Br
  • 酮酯/D-BHB/R-BHB
  • 布托溴铵
  • 29025-14-7
  • [3(S)-endo]-
  • Butropan
  • butoxybenzyl hyoscyamine
  • N-(Butoxybenzyl)hyoscyamine bromide
  • Coliopan
  • BHB
  • 8-Azoniabicyclo[3.2.1]octane, 8-[(4-butoxyphenyl)methyl]-3-(3-hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-, bromide, [3(S)-endo]-
  • 1αH,5αH-Tropanium, 8-(p-butoxybenzyl)-3α-hydroxy-, bromide, (-)-tropate (8CI)
  • (p-Butoxybenzyl)hyoscyaminium bromide
  • Butropium
  • butropium bromide

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