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MRS 2365

MRS 2365 Structure
MRS 2365
  • CAS No.436847-09-5
  • Chemical Name:MRS 2365
  • CBNumber:CB7847532
  • Molecular Formula:C13H19N5O9P2S
  • Formula Weight:483.33
  • MOL File:436847-09-5.mol
MRS 2365 Property
  • Boiling point 875.5±75.0 °C(Predicted)
  • Density 2.37±0.1 g/cm3(Predicted)
  • storage temp. Desiccate at -20°C
  • pka 1.42±0.10(Predicted)
  • form Powder
  • Water Solubility Soluble in water (supplied pre-dissolved at a concentration of 10mM)
  • FDA UNII YQI4GCR8ST
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

MRS 2365 Chemical Properties,Usage,Production

  • Uses MRS2365 is a potent and selective P2Y1 receptor (EC50=0.4 nM) /[35S]GTPγS binding/β-arrestin 2 recruitment agonist with an EC50 of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors[1][2][3][4].
  • Biological Activity Highly potent, selective P2Y 1 receptor agonist (EC 50 = 0.4 nM). Displays no activity at P2Y 12 receptors and only very low agonist activity at P2Y 13 receptors (at concentrations up to 1 μ M).
  • in vivo

    MRS2365 (0.03-0.3 mg/kg; i.p.; single dose) significantly alleviates the mechanical allodynia in the male wistar rats neuropathy (Seltzer) model with dose-dependent manner[3].
    MRS2365 (0.1-2 mg/kg; i.p.; single dose) increases the paw withdrawal threshold (PWT) in male wistar rats with neuropathic pain model[3].

    Animal Model:Male Wistar rats with neuropathic pain(250-350 g)[3].
    Dosage:0.03, 0.1, 0.3, 1 and 2 mg/kg.
    Administration:Intraperitoneal injection; single dose.
    Result:Relieved mechanical allodynia and increased the paw withdrawal threshold.
  • IC 50 P2Y1 Receptor: 0.4 nM (EC50)
  • References [1] Mariya Chhatriwala, et al. Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. J Pharmacol Exp Ther. 2004 Dec;311(3):1038-43. DOI:10.1124/jpet.104.068650
    [2] D M Bourdon, et al. (N)-methanocarba-2MeSADP (MRS2365) is a subtype-specific agonist that induces rapid desensitization of the P2Y1 receptor of human platelets. J Thromb Haemost. 2006 Apr;4(4):861-8. DOI:10.1111/j.1538-7836.2006.01866.x
    [3] Andó RD, et al. A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. Br J Pharmacol. 2010 Mar;159(5):1106-17. DOI:10.1111/j.1476-5381.2009.00596.x
    [4] Gao ZG, et al. Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor. Mol Pharmacol. 2017 Nov;92(5):613-626. DOI:10.1124/mol.117.109660
MRS 2365 Preparation Products And Raw materials
Raw materials
Preparation Products
MRS 2365 Suppliers
Global(23)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
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  • Supplier：
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  • Email：3bsc@sina.com
  • Country：China
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  • Supplier： EMMX Biotechnology LLC
  • Tel：888-539-0666
  • Email：info@emmx.com
  • Country：United States
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  • Supplier： R&D Systems, Inc
  • Tel：18003437475<br/>18003437475
  • Email：rdname@qq.com
  • Country：China
  • ProdList：35960
  • Advantage：58
MRS 2365 Spectrum
436847-09-5, MRS 2365Related Search:
  • C13H19N5O9P2S
  • C13H16N5O9P2SNa3
  • 化合物 T23022
  • 436847-09-5
  • Diphosphoric acid, P-[[(1R,2R,3S,4R,5S)-4-[6-amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] ester
  • MRS 2365, CID: 73755043
  • [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl]diphosphoricacidmonoestertrisodiumsalt
  • [[(1R,2R,3S,4R,5S)-4-[6-AMINO-2-(METHYLTHIO)-9H-PURIN-9-YL]-2,3-DIHYDROXYBICYCLO[3.1.0]HEX-1-YL]METHYL] DIPHOSPHORIC ACID MONO ESTER TRISODIUM SALT
  • MRS 2365

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