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CCPA

CCPA Structure
CCPA
  • CAS No.37739-05-2
  • Chemical Name:CCPA
  • CBNumber:CB7751716
  • Molecular Formula:C15H20ClN5O4
  • Formula Weight:369.8
  • MOL File:37739-05-2.mol
CCPA Property
  • Boiling point 656.1±65.0 °C(Predicted)
  • Density 1.87±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility H2O: 1.7 mg/mL, insoluble
  • form solid
  • pka 13.06±0.70(Predicted)
  • color off-white to light yellow
  • EWG's Food Scores 1
  • FDA UNII JX2F2W6WSP
  • UNSPSC Code 41106305
  • NACRES NA.77
Safety
  • Safety Statements  :24/25
  • WGK Germany  :3
  • RTECS  :AU7357555
  • HS Code  :29349990
  • Toxicity :mouse,LD,intraperitoneal,> 100mg/kg (100mg/kg),BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Arzneimittel-Forschung. Drug Research. Vol. 44, Pg. 1305, 1994.
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
CCPA Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: C7938
  • Product name : 2-Chloro-N6-cyclopentyladenosine
  • Purity: adenosine receptor agonist
  • Packaging: 10MG
  • Price: ₹20794.83
  • Updated: 2022/06/14
  • Buy: Buy

CCPA Chemical Properties,Usage,Production

  • Chemical Properties Solid
  • Uses 2-Chloro-N6-cyclopentyl Adenosine is a selective adenosine receptor agonist (1,2). It inhibits angiotensin II induced cardiomyocyte hypertrophy via the calcineurin signaling pathway (2).
  • Uses 2-Chloro-N6-cyclopentyladenosine (CCPA) may be used as an A1 adenosine receptor agonist with high selectivity. CCPA is often used with other adenosine receptor agonists and antagonist to resolve A(1), A(2A) and A(3) receptor functions. These include DPCPX (A(1) receptor antagonist), 4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-α][1,3,5]triazin-5-ylamino]ethyl)phenol (A(2A) receptor antagonist), and 4-[2-[[6-amino-9-(N-ethyl-β-D-ribofuranuronamidosyl)-9H-purin-2-yl]amino]ethyl]benzenepropanoic acid hydrochloride (A(2A) receptor agonist), and Cl-IB-MECA, (A(3)) receptor agonist).
  • Uses Adenosine receptors are for treating central nervous system (CNS) disorders. Adenosine A1 receptor agonists include e.g. CCPA, 8-cyclopentyl-1,3-dipropylxanthine, R-phenylisopropyl adenosine. A2A rec eptor agonists include e.g. regadenoson (Lexiscan), apadenoson, binodenoson.
  • Biological Activity Potent and selective adenosine A 1 receptor agonist (K i values are 0.8, 2300 and 42 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 18800 nM for hA 2B ). Centrally active following systemic administration in vivo .
  • Biochem/physiol Actions A1 adenosine receptor agonist with high selectivity: reportedly 10,000-fold for A1 over A2 receptors.
  • storage Desiccate at RT
  • References [1]. lohse mj, klotz kn, schwabe u, et al. 2-chloro-n6-cyclopentyladenosine: a highly selective agonist at a1 adenosine receptors. naunyn schmiedebergs arch pharmacol, 1988, 337(6): 687-689.
    [2]. monopoli a, conti a, dionisotti s, et al. pharmacology of the highly selective a1 adenosine receptor agonist 2-chloro-n6-cyclopentyladenosine. arzneimittelforschung, 1994, 44(12): 1305-1312.
    [3]. concas a, santoro g, mascia mp, et al. anticonvulsant doses of 2-chloro-n6-cyclopentyladenosine, an adenosine a1 receptor agonist, reduce gabaergic transmission in different areas of the mouse brain. j pharmacol exp ther, 1993, 267(2): 844-851.
    [4]. sandoli d, chiu pj, chintala m, et al. in vivo and ex vivo effects of adenosine a1 and a2 receptor agonists on platelet aggregation in the rabbit. eur j pharmacol, 1994, 259(1): 43-49.
CCPA Preparation Products And Raw materials
Raw materials
Preparation Products
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CCPA Spectrum
37739-05-2, CCPARelated Search:
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  • Biochemicals and Reagents
  • C15H20ClN5O4H2O
  • C15H20N5O4Cl
  • C15H20ClN5O4
  • C15H20CIN5O4
  • C15H20ClN5O405H2O
  • 化合物 CCPA,10 MM DMSO 溶液
  • 2-CHLORO-N6-CYCLOPENTYLADENOSINE (CCPA),A1激动剂
  • (2R,3R,4S,5R)-2-(2-氯-6-(环戊基氨基)-9H-嘌呤-9-基)-5-(羟甲基)四氢呋喃-3,4-二醇
  • 化合物 CCPA
  • 2-CHLORO-N(6)CYCLOPENTYLADENOSINE|||2-氯-N6-环戊基腺苷|||2-CHLORO-N-CYCLOPENTYLADENOSINE
  • 2-氯-N6-环戊基腺苷
  • 2-CHLORO-N6-CYCLOPENTYLADENOSINE 半水合物
  • 2-氯-N<SUP>6</SUP>-环戊基腺苷
  • 37739-05-2
  • CCPA, 10 mM in DMSO
  • 2-Chloro-N6-cyclopentyladenosine (CCPA), A1 agonist
  • 2-chloro-N(6)cyclopentyladenosine|||2-CHLORO-N-CYCLOPENTYLADENOSINE
  • 2 Chloro N6 cyclopentyladenosine,2ChloroN6cyclopentyladenosine,2-Chloro-N-6-cyclopentyladenosine
  • 2-Chloro-N6-cyclopentyladenosine 2-Chloro-N6-cyclopentyladenosine
  • CCPA USP/EP/BP
  • 2-Chloro-N-cyclop
  • (2R,3R,4S,5R)-2-[2-Chloro-6-(cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
  • 2-Chloro-N≤sup>=6≤/sup>=-cyclopentyladenosine
  • Adenosine, 2-chloro-N-cyclopentyl-
  • N-Cyclopentyl-2-chloroadenosine
  • 2-CHLORO-N6-CYCLOPENTYLADENOSINE (CCPA) A1 ADENOSINE RECEPTOR
  • 2-Chloro-N6-cyclopentyladenosine hemihydrate
  • 2-chloro-N(sup 6)-cyclopentyladenosine
  • 2-chloro-n-cyclopentyl-adenosin
  • 2-CHLORO-N6-CYCLOPENTYLADENOSINE
  • 2-CHLORO-N-CYCLOPENTYLADENOSINE
  • CCPA

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