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Monensin sodium salt

Monensin sodium salt Structure
Monensin sodium salt
  • CAS No.22373-78-0
  • Chemical Name:Monensin sodium salt
  • CBNumber:CB7748020
  • Molecular Formula:C36H63NaO12
  • Formula Weight:710.87
  • MOL File:22373-78-0.mol
Monensin sodium salt Property
  • Melting point 267-269 C
  • alpha 57.3 º (c=4.0, in MeOH)
  • storage temp. 2-8°C
  • solubility Soluble in methanol at 50mg/ml
  • form Off-white to beige solid
  • color White
  • BRN 4122200
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
  • InChIKey XOIQMTLWECTKJL-BEMBKCOJSA-M
  • LogP 3.716 (est)
  • FDA UNII 1GS872GAFV
  • EPA Substance Registry System Monensin, monosodium salt (22373-78-0)
  • UNSPSC Code 12352200
Safety
  • Hazard Codes  :T,T+
  • Risk Statements  :25-26/27/28
  • Safety Statements  :36/37/39-45-22
  • RIDADR  :UN 3462 6.1/PG 2
  • WGK Germany  :3
  • RTECS  :JH2830000
  • HazardClass  :6.1(a)
  • PackingGroup  :II
  • HS Code  :29419090
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300-H319-H334-H373-H411
  • Precautionary statements P260-P264-P273-P301+P310-P304+P340+P312-P305+P351+P338
Monensin sodium salt Price More Price(9)
  • Brand: Sigma-Aldrich(India)
  • Product number: M5273
  • Product name : Monensin sodium salt
  • Purity: 90-95% (TLC)
  • Packaging: 500MG
  • Price: ₹7783.18
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M5273
  • Product name : Monensin sodium salt
  • Purity: 90-95% (TLC)
  • Packaging: 1G
  • Price: ₹12167.3
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: PHR2775
  • Product name : Monensin Sodium
  • Purity: Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 300?mg
  • Packaging: 300MG
  • Price: ₹14473.03
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M5273
  • Product name : Monensin sodium salt
  • Purity: 90-95% (TLC)
  • Packaging: 5G
  • Price: ₹45378.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 46468
  • Product name : Monensin sodium salt hydrate
  • Purity: VETRANAL?, analytical standard
  • Packaging: 100MG
  • Price: ₹5585.7
  • Updated: 2022/06/14
  • Buy: Buy

Monensin sodium salt Chemical Properties,Usage,Production

  • Description Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.
  • Chemical Properties LIGHT CREAM AMORPHOUS POWDER
  • Uses Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.
  • Uses antibacterial
  • Uses antifungal
  • Uses Poliether antibiotic. Coccidiostat.
  • General Description Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.
  • Biochem/physiol Actions Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.
  • storage -20°C
  • Purification Methods Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].
  • References Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767
Monensin sodium salt Preparation Products And Raw materials
Raw materials
Preparation Products
Monensin sodium salt Suppliers
Global(359)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
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  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
Monensin sodium salt Spectrum
22373-78-0, Monensin sodium saltRelated Search:
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  • C36H61NaO11xH2O
  • C36H63NaO12
  • C36H61NaO11
  • 莫能菌酸(莫能星)
  • MONENSIN SODIUM SALT,NA+ IONOPHORE
  • 莫能霉素钠水合物
  • 莫能菌素盐
  • 莫能菌素钠盐标准品
  • 甲醇中莫能菌素钠盐溶液标准物质
  • 甲醇中莫能菌素钠盐溶液
  • 甲醇中莫能菌素盐/农业农村部公告第197号-10-2019
  • 莫能菌素钠盐|||SODIUM MONENSIN|||MONENSIN A SODIUM SALT
  • 莫能菌素纳
  • 莫能辛钠盐
  • (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-乙基-5'-((2S,3S,5R,6R)-6-羟基-6-(羟甲基)-3,5-二甲基四氢-2H-吡喃-2-基)-3'-甲基八氢-[2,2'-二呋喃]-5-基)-9-羟基-2,8-二甲基-1,6-二氧杂螺[4.5]癸烷-7-基)-3-甲氧基-2-甲基戊酸钠盐
  • 莫能星钠盐
  • 莫能菌素/莫能菌素钠盐/莫能菌素钠

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