Chemical Properties
Colorless or light yellow viscous oily liquid. Easy to absorb moisture, unstable. Acid, alkali, heat can accelerate its decomposition. It is insoluble in benzene, chloroform, slightly soluble in ether, pentanol, soluble in water, ethyl acetate, dioxane and glacial acetic acid.
Physical properties
Pantothenic acid is composed of β-alanine joined to 2,4-dihydroxy-3,3-
dimethylbutyric acid via an amide linkage. The molecule has an asymmetric center,
and only the R-enantiomer, usually called D-(+)pantothenic acid, is biologically
active and occurs naturally. Appearance: pantothenic acid is a yellow, viscous oil.
Its calcium and other salts, however, are colorless crystalline substances; calcium
pantothenate is the main product of commerce. Solubility: neither form is soluble in
organic solvents, but each is soluble in water and ethanol. Stability: aqueous solu tions of pantothenic acid are unstable when heated under acidic or alkaline
conditions
Originator
Panto-250 , Bio-Tech Pharmacal
Uses
Pantothenic Acid is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.
Uses
Vitamin B5 is water-soluble. It is required for proper growth and maintenance of the body and is involved in body processes such as energy release from carbohydrates and metabolism of fatty acids. It is relatively stable through storage and is found in liver, eggs, and meat.
Uses
Labelled Pantothenic Acid
Definition
ChEBI: (R)-pantothenic acid is a pantothenic acid having R-configuration. It has a role as an antidote to curare poisoning, a human blood serum metabolite and a geroprotector. It is a vitamin B5 and a pantothenic acid. It is a conjugate acid of a (R)-pantothenate.
Manufacturing Process
Isobutylaldehyde reacted with formaldehyde in the presence potassium chromate as a result 2,2-dimethyl-3-hydroxy-propanal was obtained.
The 2,2-dimethyl-3-hydroxy-propanal was treated by sodium cyanide so 2,4dihydroxy-3,3-dimethyl-butironitrile was prepared.
The 2,4-dihydroxy-3,3-dimethyl-butironitrile was treated hydrochloric acid and D,L-3-hydroxy-4,4-dimethyl-dihydro-furan-2-one (D,L-pantolacton) was obtained. The racemic mixture of D- and L-pantolactons was a division of Dand L- isomers by the adding of α-phenylethylamine. So D-pantolacton was isolated.
Acrylic acid contacted with NH3and β-alanine was obtained.
D-Pantalacton reacted with β-alanine as a result 3-(2,4-dihydroxy-3,3dimethyl-butyrylamino)-propanoic acid was produced
brand name
Calpan (BASF); Pantholin
(Lilly).
Therapeutic Function
Vitamin
Safety Profile
Moderately toxic by subcutaneous and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NOx.
