(-)-4-Bromotetramisole oxalate

Description

Four distinct human isoenzymes of alkaline phosphatase (AP) are known: intestinal (IAP), placental (PLAP), tissue non-specific (NSAP, also known as liver/bone/kidney AP), and germ cell AP (also known as placental-like AP, PLAP-like). L-p-Bromotetramisole is a cell-permeable inhibitor of all four human AP isoenzymes (K_is =18 and 56 μM for PLAP and NSAP, respectively). While PLAP is strongly inhibited by L-p-bromotetramisole, a second AP, possibly PLAP-like, shows only partial inhibition. L-p-Bromotetramisole has been shown to inhibit a tyrosine phosphatase from Drosophila and, as a result, is also used as a tyrosine phosphatase inhibitor.

Chemical Properties

white to light yellow crystal powde

Uses

L-p-Bromotetramisole Oxalate or (-)-p-Bromotetramisole Oxalate is a potent inhibitor of alkaline phosphatase.

Biochem/physiol Actions

(-)-p-Bromolevamisole oxalate inhibits L-isoforms of alkaline phosphatases.

target

alkaline phosphatase

References

[1] J S KOVACH  D J S  P A Svingen. Levamisole potentiation of fluorouracil antiproliferative activity mimicked by orthovanadate, an inhibitor of tyrosine phosphatase.[J]. JNCI Journal of the National Cancer Institute, 1992, 84 7: 515-519. DOI:10.1093/jnci/84.7.515
[2] J LUO. Role of protein phosphatases in the activation of CFTR (ABCC7) by genistein and bromotetramisole.[J]. American journal of physiology. Cell physiology, 2000, 279 1: C108-19. DOI:10.1152/ajpcell.2000.279.1.c108
[3] B M SCHER. The phosphatase inhibitors, orthovanadate and levamisole, inhibit induction of erythroid differentiation and abrogate the associated inhibition of glycolysis.[J]. International journal of oncology, 1998, 12 5: 987-996. DOI:10.3892/ijo.12.5.987