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(-)-N-METHYLEPHEDRINE

CAS No.552-79-4
Chemical Name:(-)-N-METHYLEPHEDRINE
CBNumber:CB7495234
Molecular Formula:C11H17NO
Formula Weight:179.26
MOL File:552-79-4.mol

(-)-N-METHYLEPHEDRINE Property

Melting point 86-88 °C(lit.)
Boiling point 311.8°C (rough estimate)
Density 1.0020 (rough estimate)
refractive index 1.5065 (estimate)
Flash point 9℃
storage temp. Refrigerator (+4°C)
pka pKa 9.257(H2O,t =25,I=0.00) (Uncertain)
form Powder
Sensitive Moisture Sensitive
Merck 14,6068
CAS DataBase Reference 552-79-4(CAS DataBase Reference)
FDA UNII 60VH42A1KJ
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi,T,F
Risk Statements :36/37/38-39/23/24/25-23/24/25-11
Safety Statements :26-36-45-36/37-16-7
RIDADR :1544
WGK Germany :3
F :3
HazardClass :6.1(b)
PackingGroup :III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H301+H311+H331-H370-H302-H315-H319-H335
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P210-P260-P280-P301+P310-P311

(-)-N-METHYLEPHEDRINE Chemical Properties,Usage,Production

Description The Chinese plant 'Ma-Huang' contains this alkaloid, first isolated by Smith. According to Read, the name 'Ma-Huang' is the name for various Ephedra species but the material principally used in China is E. sinica Stapf. (Syn. E. j7ava Porter Smith, E. Mahuang Liu). It has subsequently been discovered in European species, notably E. helvetica C. A. Meyer and E. distachya Linn. The alkaloid crystallizes in stout, colourless needles and has [α]_D - 29.2° (MeOH). It yields several crystalline salts and derivatives: hydrochloride, m.p. 188-9°C; [α]²⁰_D - 29.8° (H20); oxalate, m.p. 187°C; aurichloride, m.p. 128-9°C; picrate, m.p. 144°C and the methiodide, m.p. 212-3°C; [α]_D - 21.8° (H20).
Chemical Properties White crystals or adhering crystalline powder
Uses adrenergic agonist, analeptic
Uses Used in conjunction with LiAlH4 for chiral reductions
Definition ChEBI: (1R,2S)-2-(dimethylamino)-1-phenyl-1-propanol is an alkylbenzene.
Purification Methods N-Methylephedrine has been recrystallised from Et2O, pet ether, of aqueous EtOH or aqueous MeOH and has been distilled under reduced pressure. [Smith J Chem Soc 2056 1927, Tanaka & Sugawa Yakugaku Zasshi (J Pharm Soc Japan) 72 1548 1952 (Chem Abstr 47 8682 1953), Takamatsu Yakugaku Zasshi (J Pharm Soc Japan) 76 1227 1956, Chem Abstr 51 4304 1957.] The hydrochloride has m 192-193o and [] D (c 5,H2O)[Prelog & Hüfliger Helv Chim Acta 33 2021 1950].20+30o [Beilstein 13 IV 1884.]
References Smith., J. Chern. Soc., 2056 (1927)
Smith., ibid, 51 (1928)
Smith., ibid, 2755 (1929)
Wolfes., Arch. Pharrn., 268,327 (1930)
Preparation:
Nagai., J. Pharrn. Soc., Japan, No. 120, 109 (1892)
Nagai, Kanao., ibid, 48, 145 (1928)

(-)-N-METHYLEPHEDRINE Preparation Products And Raw materials

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Preparation Products

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(-)-N-METHYLEPHEDRINE Spectrum

(-)-N-METHYLEPHEDRINE(552-79-4)MS (-)-N-METHYLEPHEDRINE(552-79-4)¹HNMR (-)-N-METHYLEPHEDRINE(552-79-4)IR1 (-)-N-METHYLEPHEDRINE(552-79-4)IR2 (-)-N-METHYLEPHEDRINE(552-79-4)Raman

552-79-4, (-)-N-METHYLEPHEDRINERelated Search:

Trecadrine (1S,2R)-N-TOSYLEPHEDRINE (+)-Bicuculline (1R,2S)-2-DI-N-BUTYLAMINO-1-PHENYL-1-PROPANOL tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate (S)-(+)-2-[HYDROXY(DIPHENYL)METHYL]-1-METHYLPYRROLIDINE L-N-METHYLEPHEDRINE HYDROCHLORIDE, 99 (-)-BETA-HYDRASTINE Ipenoxazone (-)-N-METHYLEPHEDRINE (-)-BICUCULLINE METHOBROMIDE (-)-N-DODECYL-N-METHYLEPHEDRINIUM BROMIDE dl-Methylephedrine HCl ,dl-methylephedrine hydrochloride L-N-METHYLEPHEDRINE HYDROCHLORIDE,METHYLEPHEDRINE HCL,(IR,2S)-I-N-Methylephedrine HCL (+)-N-METHYLEPHEDRINE 1-Phenyl-1-propanol Ephedrine

Pharmaceutical Raw Materials
Ephedrine Derivatives
Chiral Auxiliaries
Asymmetric Synthesis
C6H5CHOHCHCH3NCH32
标准品/甲醇中甲基麻黄碱/厂家效期大于3个月正常供货
甲醇中甲基麻黄碱
麻黄碱杂质4
甲基麻黄碱溶液,100PPM
甲醇测试标样(甲基麻黄碱)
(-)-N-甲基麻黄碱,98+%
4-甲麻黄碱
哮喘特灵
[R-(R*,S*)]-Α-[1-(二甲基氨基)乙基]苯甲醇
(1R,2S)-(-)-N-甲基麻黄碱
(-)-(1R,2S)-2-二甲基氨基-1-苯丙醇
(1R,2S)-(-)-2-二甲基氨基-1-苯丙醇
(-)-N-甲基麻黄碱
甲麻黄碱
甲基麻黄素
甲基麻黄碱
552-79-4
Methylephedrine ((1R,2S)-Methylephedrine)
METHYLEPHEDRINE
(-)-ALPHA-[1-(DIMETHYLAMINO)ETHYL]BENZENEMETHANOL
L-N-METHYLEPHEDRINE
2-(Dimethylamino)-1-phenyl-1-propanol
(-)-(1R,2S)-2-DIMETHYLAMINO-1-PHENYL-1-PROPANOL
(-)-1R,2S N-METHYLEPHEDRINE
(-)-Methylephedrine
(-)-N-METHYLEPHEDRINE USP/EP/BP
Cinchocaine Solution, 100ppm
(1R,2S)-(-)-N--Methylephedrine solution
(-)-N-METHYLEPHEDRINE
[R-(R*,S*)]-ALPHA-[1-(DIMETHYLAMINO)ETHYL]BENZENEMETHANOL
N,N-Dimethylnorephedrine2-dimethylamino-1-phenylpropanol
N,N-Dimethylnorephedrine
Erythro-alpha-[1-(dimethylamino)ethyl]benzyl alcohol
Benzenemethanol, alpha-[1-(dimethylamino)ethyl]-, [R-(R*,S*)]-
METHYLEPHEDRINE, (-)-1R,2S N-
METHYLEPHEDRINE, (-)-1R,2S-
Dimethyl-ephedrine
[R,(-)]-α-[(S)-1-(Dimethylamino)ethyl]benzyl alcohol
-[1-(Dimethylamino)ethyl]benzenemethanol
(1Rs,2Rs)-2-dimethylamino-1-phenylpropan-1-ol
Methylephedrine solution
N-METHYL (-)EPHEDRINE [1R,2S]
Methanol(Test Methylephedrine, 1.0 mg/mL)
[R-(R,S)]-α-[1-(Dimethylamino)ethyl]benzenemethanol
(-)-N-Methylephedrine,99%
(-)-N-Methylephedrine, (-)-(1R,2S)-2-Dimethylamino-1-phenylpropanol, [R-(R*,S*)]-α-[1-(Dimethylamino)ethyl]benzenemethanol
(-)-N-Methylephedrine, 98+%
N-Methylephedrine (base and/or unspecified salts)
METHYLEPHEDRINE, (-)-1R,2S SNAPN 1.0mg/mL(SH)
(IR,2S)-I-N-Methylephedrine Base
(-)-(1R,2S)-2-DIMETHYLAMINO-1-PHENYLPROPANOL
(-)-1R,2S-METHYLEPHEDRINE
(1R,2S)-(-)-N-METHYLEPHEDRINE

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