4-Chloro-2-hydroxypyridine

Uses

4-Chloro-2-hydroxypyridine serves as a precursor for the synthesis of 4-chloropyridin-2-yl trifluoromethanesulfonate [1].

Synthesis

4-Chloro-2-hydroxypyridine forms via chlorination and elimination reactions involving HCl loss and decarboxylation that facilitate cyclization, and is also generated during controlled chloramination and chlorination of surface water [2].

References

[1] Reeves, E. K., Humke, J. N., & Neufeldt, S. R. (2019). N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki–Miyaura Cross Coupling. The Journal of Organic Chemistry, 84(18), 11799–11812. https://doi.org/10.1021/acs.joc.9b01692
[2] Wang, P., Ye, B., Nomura, Y., & Fujiwara, T. (2025). Emerging heterocyclic nitrogenous disinfection byproducts: Occurrence, precursors, and mechanisms of halogenated pyridines. Journal of Environmental Chemical Engineering, 13(6), 120309. https://doi.org/10.1016/j.jece.2025.120309