Synthesis
To a solution of cyclopropylamine (50.0 g, 0.876 mol) in dichloromethane (700 mL) was added 2-chloroacetyl chloride (49.4 g, 0.436 mol) slowly and dropwise through an addition funnel at 0 °C. The reaction mixture was stirred continuously at 0 °C for 2 h, followed by filtration through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give an orange solid. The solid was slurried in 500 mL of hexane and filtered again. The collected orange solid was dried under vacuum at room temperature for 30 min to give the final 2-chloro-N-cyclopropylacetamide (58.12 g, 99% yield). Mass spectrometry analysis (m/z): 134.1 (M++1).
References
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[4] Patent: CN106146414, 2016, A. Location in patent: Paragraph 0478; 0479; 0480
[5] ChemMedChem, 2018,
