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ERGOLIDE

ERGOLIDE Structure
ERGOLIDE
  • CAS No.54999-07-4
  • Chemical Name:ERGOLIDE
  • CBNumber:CB7410891
  • Molecular Formula:C17H22O5
  • Formula Weight:306.35
  • MOL File:54999-07-4.mol
ERGOLIDE Property
  • storage temp. 4°C, protect from light
  • solubility DMSO: 50 mg/mL (163.21 mM)
  • form Solid
  • color White to off-white
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

ERGOLIDE Chemical Properties,Usage,Production

  • Uses Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB[1].
  • Definition ChEBI: Ergolide is a sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetyloxy group at position 4. It has been isolated from the aerial parts of Inula hupehensis. It has a role as a metabolite, an anti-inflammatory agent, a plant metabolite, an antineoplastic agent and a NF-kappaB inhibitor. It is a gamma-lactone, a cyclic ketone, an acetate ester, an organic heterotricyclic compound and a sesquiterpene lactone.
  • IC 50 NF-κB
  • References [1] Whan Han J, et al. Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB. Br J Pharmacol. 2001 Jun;133(4):503-12. DOI:10.1038/sj.bjp.0704099
ERGOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ERGOLIDE Suppliers
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ERGOLIDE Spectrum
54999-07-4, ERGOLIDERelated Search:
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  • Ergolide, 10 mM in DMSO
  • Nuclear factor-kappaB,Ergolide,Nuclear factor-κB,Inhibitor,NF-κB,inhibit
  • ERGOLIDE USP/EP/BP
  • Azuleno[6,5-b]furan-2,5-dione, 4-(acetyloxy)decahydro-4a,8-dimethyl-3-methylene-, (3aR,4S,4aR,7aS,8R,9aS)-
  • Dihydrobigelovin
  • (3aR,4S,4aR,7aS,8R,9aS)-4a,8-Dimethyl-3-methylene-2,5-dioxododecahydroazuleno[6,5-b]furan-4-yl acetate
  • (3aR,7aα,9aβ)-4α-Acetyloxy-3-methylene-4aβ,8α-dimethyldecahydroazuleno[6,5-b]furan-2,5-dione
  • ERGOLIDE

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