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BMY 7378 DIHYDROCHLORIDE

BMY 7378 DIHYDROCHLORIDE Structure
BMY 7378 DIHYDROCHLORIDE
  • CAS No.21102-95-4
  • Chemical Name:BMY 7378 DIHYDROCHLORIDE
  • CBNumber:CB7388662
  • Molecular Formula:C22H32ClN3O3
  • Formula Weight:421.97
  • MOL File:21102-95-4.mol
BMY 7378 DIHYDROCHLORIDE Property
  • storage temp. Inert atmosphere,Room Temperature
  • solubility H2O: soluble
  • form solid
  • color white
  • Water Solubility Soluble to 100 mM in water
  • FDA UNII KC07KV8T5O
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • RTECS  :GY3996000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
BMY 7378 DIHYDROCHLORIDE Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: B134
  • Product name : BMY 7378 dihydrochloride
  • Purity: ≥98% (HPLC), solid
  • Packaging: 25MG
  • Price: ₹23660
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: B134
  • Product name : BMY 7378 dihydrochloride
  • Purity: ≥98% (HPLC), solid
  • Packaging: 100MG
  • Price: ₹70925.4
  • Updated: 2022/06/14
  • Buy: Buy

BMY 7378 DIHYDROCHLORIDE Chemical Properties,Usage,Production

  • Uses BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist.
  • Biological Activity 5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ .
  • Biochem/physiol Actions BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist.
  • IC 50 rat α1A-adrenergic receptor: 800 nM (Ki); hamster alpha1B-adrenergic receptor: 600 nM (Ki); rat alpha1D-adrenergic receptor: 2 nM (Ki); 5-HT1A Receptor
  • storage Room temperature
  • References 1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40.
BMY 7378 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BMY 7378 DIHYDROCHLORIDE Suppliers
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BMY 7378 DIHYDROCHLORIDE Spectrum
21102-95-4, BMY 7378 DIHYDROCHLORIDERelated Search:
  • Inhibitors
  • Serotonin receptor
  • 抑制剂
  • 药靶配体
  • 神经信号
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • C22H31N3O32HCl
  • C22H33Cl2N3O3
  • 化合物BMY 7378 DIHYDROCHLORIDE,10 MM DMSO 溶液
  • BMY 7378 DIHYDROCHLORIDE,5-HT1A PARTIAL激动剂. ALPHA ADRENOCEPTOR拮抗剂.
  • 8-(2-(4-(2-甲氧基苯基)哌嗪-1-基)乙基)-8-氮杂螺[4.5]癸烷-7,9-二酮 二盐酸盐
  • 8-[2-[4-(2-甲氧基苯基)-1-哌嗪基]乙基]-8-氮杂螺[4.5]癸烷-7,9-二酮 盐酸盐 (1:2)
  • 化合物BMY 7378 DIHYDROCHLORIDE
  • BMY7378二盐酸盐
  • BMY7378抑制剂
  • 8-[2-[4-(2-甲氧基苯基)-1-哌嗪基]乙基]-8-氮杂螺[4.5]癸烷-7,9-二酮盐酸盐
  • 8-[2-[4-(甲氧基苯基)-1-哌嗪]乙基]-8-氮杂螺[4.5]癸烷-7,9-二酮双盐酸盐
  • 21102-95-4
  • BMY 7378 dihydrochloride, 10 mM in DMSO
  • BMY 7378 dihydrochloride, 5-HT1A partial agonist. alpha adrenoceptor antagonist.
  • BMY7378,BMY-7378 dihydrochloride
  • 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride (1:2)
  • 8-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-8-azaspiro[4....
  • BMY 7378 DIHYDROCHLORIDE USP/EP/BP
  • CS-1419
  • BMY7378;BMY-7378
  • 8-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-8-azaspiro[4.5]decane-7,9-dione dihydrochloride
  • 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride
  • N-(2-(4-(o-Methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimide dihydrochloride
  • BMY 7378 DIHYDROCHLORIDE;8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4,5)DECANE-7,9-DIONE DIHYDROCHLORIDE
  • 1,1-Cyclopentanediacetimide, N-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-, dihydrochloride
  • BMY 7378 DIHYDROCHLORIDE
  • 8-(2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL)-8-AZASPIRO(4.5)DECANE-7,9-DIONE DIHYDROCHLORIDE
  • 8-[2-[4-(METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE DIHYDROCHLORIDE
  • BMY 7378, >=98%
  • 8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride BMY7378
  • 8-Azaspiro[4.5]decane-7,9-dione, 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-, hydrochloride (1:2)
  • BMY73782HCl
  • BMY 7378 DIHYDROCHLORIDE >98% PARTIAL 5- HT1A SEROTO
  • n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimided
  • 1-cyclopentanediacetimide,n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-d
  • BMY7378 HCl
  • -8-azaspiro[4.5]decane-7,9-dione dihydrochloride
  • 8-(2-(4-(2-Methoxyphenyl)
  • BMY 7378 DIHYDROCHLORIDE;BMY 7378
  • BMY 7378 2hydrochloride

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