SB 218795

SB 218795 Structure
SB 218795
  • CAS No.174635-53-1
  • Chemical Name:SB 218795
  • CBNumber:CB7376630
  • Molecular Formula:C25H20N2O3
  • Formula Weight:396.44
  • MOL File:174635-53-1.mol
SB 218795 Property
  • Boiling point 623.7±55.0 °C(Predicted)
  • Density 1.237±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: 40 mg/mL, soluble
  • form solid
  • pka 11.41±0.46(Predicted)
  • color white
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

SB 218795 Chemical Properties,Usage,Production

  • Uses SB 218795 is an NK3 receptor antagonist.
  • Definition ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.
  • Biological Activity Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.
  • in vivo

    SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%[2].

  • IC 50 hNK3: 13 nM (Ki); hNK2: 1220 nM (Ki)
SB 218795 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 218795 Suppliers
Global(40)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
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  • Supplier：
  • Tel：821-50328103-801<br/>18930552037
  • Email：3bsc@sina.com
  • Country：China
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  • Supplier： EMMX Biotechnology LLC
  • Tel：888-539-0666
  • Email：info@emmx.com
  • Country：United States
  • ProdList：8447
  • Advantage：60
SB 218795 Spectrum
174635-53-1, SB 218795Related Search:
  • 化学试剂
  • 抑制剂
  • 合成有机化合物配体
  • 化合物SB 218795,10 MM DMSO 溶液
  • SB 218795,非肽NK3拮抗剂
  • (R)-2-苯基-2-(2-苯基喹啉-4-甲酰胺)乙酸甲酯
  • (R)-2-苯基-2-(2-苯基喹啉-4-甲酰胺基)乙酸甲酯
  • 化合物SB 218795
  • 化合物 T23316
  • 174635-53-1
  • T23316
  • SB 218795, 10 mM in DMSO
  • Methyl (R)-2-phenyl-2-(2-phenylquinoline-4-carboxamido)acetate
  • Benzeneacetic acid, α-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (αR)-
  • constriction,SB-218795,Neurokinin Receptor,Inhibitor,neurokinin-3,NK receptor,pupillary,inhibit,Tachykinin receptor,SB218795,SB 218795,NK-3
  • methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate
  • Sb 218795r
  • Benzeneacetic acid, alpha-(((2-phenyl-4-quinolinyl)carbonyl)amino)-, methyl ester, (alphar)-
  • (-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide
  • (R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID
  • (-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE
  • SB 218795

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