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Flavopiridol

Flavopiridol Structure
Flavopiridol
  • CAS No.146426-40-6
  • Chemical Name:Flavopiridol
  • CBNumber:CB7362013
  • Molecular Formula:C21H20ClNO5
  • Formula Weight:401.84
  • MOL File:146426-40-6.mol
Flavopiridol Property
  • Melting point 52.5 °C
  • Boiling point 603.6±55.0 °C(Predicted)
  • Density 1.448±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility insoluble in H2O; ≥40.2 mg/mL in DMSO; ≥85.4 mg/mL in EtOH with gentle warming and ultrasonic
  • form Yellow powder.
  • pka 6.16±0.40(Predicted)
  • color Light yellow to yellow
  • InChIKey BIIVYFLTOXDAOV-YVEFUNNKSA-N
  • SMILES C1(C2=CC=CC=C2Cl)OC2=C([C@H]3CCN(C)C[C@H]3O)C(O)=CC(O)=C2C(=O)C=1
  • CAS DataBase Reference 146426-40-6(CAS DataBase Reference)
  • NCI Dictionary of Cancer Terms alvocidib; flavopiridol; HMR 1275
  • FDA UNII 45AD6X575G
  • NCI Drug Dictionary alvocidib
Safety
  • HS Code  :2934999090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

Flavopiridol Chemical Properties,Usage,Production

  • Uses Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.
  • Uses Antineoplastic (cyclin-dependent kinase inhibitor)[Note—The trivial name, flavopiridol, has appeared in literature].
  • Definition ChEBI: Alvocidib is a synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. It has a role as an antineoplastic agent, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor, an antirheumatic drug and an apoptosis inducer. It is a dihydroxyflavone, a hydroxypiperidine, a member of monochlorobenzenes and a tertiary amino compound. It is a conjugate base of an alvocidib(1+).
  • Anticancer Research It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).
  • IC 50 CDK1/Cyc B1: 30 nM (IC50); CDK2/Cyc E: 170 nM (IC50); CDK4/Cyc D1: 100 nM (IC50); MAP: 19000 nM (IC50); PKC: 14000 nM (IC50); EGFR: 22000 nM (IC50)
Flavopiridol Preparation Products And Raw materials
Raw materials
Preparation Products
Flavopiridol Suppliers
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Flavopiridol Spectrum
146426-40-6, FlavopiridolRelated Search:
  • APIS
  • API intermediates
  • 生物试剂
  • 合成有机化合物配体
  • 化工原料
  • 原料药
  • 标准品 -中药标准品
  • 中药对照品
  • 细胞生物学试剂
  • 抑制剂
  • 植物提取物
  • 细胞周期
  • 科研试剂
  • C21H20ClNO5
  • 夫拉平度,10 MM DMSO 溶液
  • L868275|||ALVOCIDIB|||夫拉平度|||NSC 649890 HCL|||HMR-1275
  • FLAVOPIRIDOL-ALVOCIDIB-中间体
  • CDK广谱抑制剂(FLAVOPIRIDOL)
  • 夫拉平度(ALVOCIDIB)
  • 夫拉平度
  • 2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-
  • 夫拉平度2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-4-酮
  • 2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-4-酮
  • 盐酸夫拉平度
  • 弗拉平度
  • 蛋白激酶抑制剂 抗癌药
  • 146426-40-6
  • Flavopiridol, 10 mM in DMSO
  • Donepezil Impurity 63
  • L868275|||Alvocidib|||NSC 649890 HCl|||HMR-1275
  • Alvocidib
  • FLAVOPIRIDOL (ALVOCIDIB; L868275; HMR-1275)
  • HMR-1275; L86-8275
  • Flavopiridol (HMR-1275, Alvocidib, L868275)
  • CS-180
  • Flavopiridol, >=99%
  • Alvocidib(Flavopiridd)
  • Flavopiridol 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • Alvocidib, Free Base
  • FLAVOPIRIDOL; HMR-1275;L868275
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-Methylpiperidin-4-yl]-4H-chroMen-4-one
  • vopiridol(Alvocidib)
  • Flavopiridol(Alvocidib)
  • Flavopirodol
  • L86-8275
  • L-868275
  • L 868275
  • Hmr 1275
  • C077990
  • (-)cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
  • 4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-
  • 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]chromen-4-one
  • FLAVOPIRIDOL

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