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PAPA NONOATE

PAPA NONOATE Structure
PAPA NONOATE
  • CAS No.146672-58-4
  • Chemical Name:PAPA NONOATE
  • CBNumber:CB7360963
  • Molecular Formula:C6H16N4O2
  • Formula Weight:176.22
  • MOL File:146672-58-4.mol
PAPA NONOATE Property
  • Boiling point 277.2±42.0 °C(Predicted)
  • Density 1.20±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility Soluble in Water or Ethanol.
  • form White to off-white solid.
  • pka 5.55±0.69(Predicted)
  • color Off-white
  • Stability Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use.
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501

PAPA NONOATE Chemical Properties,Usage,Production

  • Description PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.
  • Uses PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade.
  • Definition ChEBI: PAPA NONOate is an alkylamine.
  • in vivo

    PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2].

    Animal Model:Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2]
    Dosage:100 μM
    Administration:Wounds received 100 μM PAPA NONOate in phosphate buffer
    Result:Increased the wound healing rate in test group.
  • References 1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281
PAPA NONOATE Preparation Products And Raw materials
Raw materials
Preparation Products
PAPA NONOATE Suppliers
Global(66)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：52924
  • Advantage：58
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：96815
  • Advantage：76
  • Supplier： Energy Chemical
  • Tel：021-58432009<br/>400-005-6266
  • Email：marketing1@energy-chemical.com
  • Country：China
  • ProdList：44812
  • Advantage：58
PAPA NONOATE Spectrum
146672-58-4, PAPA NONOATERelated Search:
  • 抑制剂
  • Application Index
  • Cell Signaling Enzymes
  • Biochemicals and Reagents
  • BioChemical
  • Nitric Oxide Metabolism
  • Enzymes, Inhibitors, and Substrates
  • NO Donors
  • C6H16N4O2
  • PAPA NONOATE,NITRIC OXIDE (NO) DONOR
  • 化合物 PAPA NONOATE
  • 146672-58-4
  • PAPA NONOate, Nitric oxide (NO) donor
  • 1-Propanamine, 3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)-
  • 3-[[nitroso(oxido)amino]-propylamino]propylazanium
  • 3-(2-Hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine, NOC-15
  • 3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine
  • PAPA NONATE
  • NOC-15 NONOATE
  • NOC-15
  • PAPA NONOATE
  • PAPA/NO
  • PROPYLAMINE PROPYLAMINE NONOATE
  • (Z)-1-[N-(3-AMINOPROPYL)-N-)B-PROPYL)AMINO]DIAZIN-1-IUM-1,2-DIOLATE
  • (Z)-1-[N-(3-AMMONIOPROPYL)-N-(N-PROPYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE
  • 1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-PROPYL-1-TRIAZENE
  • 3-(2-HYDROXY-2-NITROSO-1-PROPYLHYDRAZINO)-1-PROPANAMINE NONOATE

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