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DIPHENYLENEIODONIUM CHLORIDE

CAS No.4673-26-1
Chemical Name:DIPHENYLENEIODONIUM CHLORIDE
CBNumber:CB7355273
Molecular Formula:C12H8ClI
Formula Weight:314.55
MOL File:4673-26-1.mol

DIPHENYLENEIODONIUM CHLORIDE Property

Melting point 312-322 °C
storage temp. room temp
solubility Soluble in DMSO (up to 5 mg/ml with warming)
form Powder
color Off-white
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
FDA UNII 7M9D81YZ2N
UNSPSC Code 12352200
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36
Safety Statements :26
WGK Germany :3
HS Code :29310099

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H319
Precautionary statements P264-P280-P305+P351+P338-P337+P313P

DIPHENYLENEIODONIUM CHLORIDE Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: D2926
Product name : Diphenyleneiodonium chloride
Purity: ≥98%
Packaging: 10MG
Price: ₹13899.3
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: D2926
Product name : Diphenyleneiodonium chloride
Purity: ≥98%
Packaging: 50MG
Price: ₹47294.43
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 300260
Product name : Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem
Purity: A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS).
Packaging: 10MG
Price: ₹11880.01
Updated: 2022/06/14
Buy: Buy

Brand: ALFA India
Product number: ALF-J64838-MF
Product name : Diphenyleneiodonium chloride
Purity:
Packaging: 50mg
Price: ₹45716
Updated: 2022/05/26
Buy: Buy

Brand: ALFA India
Product number: ALF-J64838-MC
Product name : Diphenyleneiodonium chloride
Purity:
Packaging: 100mg
Price: ₹86010
Updated: 2022/05/26
Buy: Buy

DIPHENYLENEIODONIUM CHLORIDE Chemical Properties,Usage,Production

Description Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC₅₀ = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC₅₀ = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.
Chemical Properties Crystalline Solid
Uses Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Uses Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Definition ChEBI: An organic chloride salt having dibenziodolium as the counterion.
Biochem/physiol Actions A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.
storage Desiccate at -20°C
References 1) Stuehr?et al.?(1991),?Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs; FASEB J.,?5?98 2) Yea?et al.?(1990),?Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase; Biochem. J.,?265?95 3) Ye?et al.?(2014),?Identification of a novel small-molecule agonist for human G protein-coupled receptor 3; J. Pharmacol. Exp. Ther.,?349?4371 4) Mendes?et al.?(2001),?Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species; Mediators Inflamm.,?10?209 5) Kono?et al.?(2001),?Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat;?Am. J. Physiol. Gastrointest. Liver Physiol.,?280?G1005