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2-Methoxy-5-sulfamoylbenzoic acid

2-Methoxy-5-sulfamoylbenzoic acid Structure
2-Methoxy-5-sulfamoylbenzoic acid
  • CAS No.22117-85-7
  • Chemical Name:2-Methoxy-5-sulfamoylbenzoic acid
  • CBNumber:CB7354418
  • Molecular Formula:C8H9NO5S
  • Formula Weight:231.23
  • MOL File:22117-85-7.mol
2-Methoxy-5-sulfamoylbenzoic acid Property
  • Melting point 220 °C
  • Boiling point 482.5±55.0 °C(Predicted)
  • Density 1.492±0.06 g/cm3(Predicted)
  • storage temp. Room Temperature
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 3.56±0.10(Predicted)
  • color White to Off-White
  • CAS DataBase Reference 22117-85-7(CAS DataBase Reference)
  • FDA UNII ZK66UU128U
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :36/37/38
  • Safety Statements  :26-36/37/39
  • Hazard Note  :Irritant
  • HS Code  :2922500090
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a

2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Usage,Production

  • Uses 2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
  • Preparation Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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2-Methoxy-5-sulfamoylbenzoic acid Spectrum
22117-85-7, 2-Methoxy-5-sulfamoylbenzoic acidRelated Search:
  • Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
  • Organic acids
  • 抑制剂
  • 高端化学
  • 标准品
  • 杂质对照品
  • 对照品-杂质对照品
  • 小分子抑制剂
  • C8H8NO5S
  • 舒必利杂质D,10 MM DMSO 溶液
  • 2-甲氧基-5-胺磺酰胺苯甲酸
  • 舒必利杂质D (EP)
  • 2-甲氧基-5-氨磺基苯甲酸
  • 舒必利EP杂质D
  • 左磺舒必利-EP杂质D
  • 2-甲氧基-5-氨磺酰苯甲酸
  • 2-(溴甲基)苯甲腈
  • 2-甲氧基-5-氨基磺酰基苯甲酸
  • 2-甲氧基-5-氨磺酰苯甲酸,97%
  • 2-甲氧基-5-胺磺酰基苯甲酸
  • 舒必利杂质D
  • 2-甲氧基-5-磺酰胺基苯甲酸
  • 5-氨磺酰基-2-甲氧基苯甲酸
  • 2-甲氧基-5-胺磺酰基苯甲酸乙酯
  • 2-甲氧基-5-胺磺酰基苯甲酸 (舒必利中间体)
  • 2-甲氧基-5-磺酰苯甲酸
  • 22117-85-7
  • 2-Methoxy-5-sulfamoylbenzoic acid, 10 mM in DMSO
  • Sulpride Impurity D
  • 2-Methoxy-5-sulfamoylbenzoicaci
  • 5-[(Aminoperoxy)thio]-2-methoxybenzoic Acid
  • Levosulpiride - EP Impurity D
  • Sulpiride EP Impurity D
  • Sulpiride Impurity 4（Sulpiride EP Impurity D）
  • 6-methoxy-3-sulfonyl-1-cyclohexa-1,5-dienecarboxylic acid
  • Sulpiride Impurity D(EP)
  • carbazole2-Methoxy-5-sulfamoylbenzoic acid
  • Benzoic acid,5-(aMinosulfonyl)-2-Methoxy-
  • 3-Carboxy-4-methoxybenzenesulphonamide, 5-(Aminosulphonyl)-o-anisic acid
  • Sulpiride IMpurity D
  • 2-METHOXY-5-SULFAMOYLBENZOIC ACIDSULPIRIDE
  • 5-SulfaMoyl-o-anisic Acid
  • 2-Methoxy-5-sulfaMidobenzoic Acid
  • 3-Carboxy-4-methoxybenzenesulphonamide
  • 2-METHOXY-5-SULFONAMIDOBENZOIC ACID
  • 5-(Aminosulphonyl)-2-methoxybenzoic acid
  • 5-sulphamoyl-o-anisic acid
  • 5-Aminosulfonyl-2-Methoxybenzoic Acid
  • 2-Methoxy-5-Sufamoyl Benzoic Acid
  • 3-CARBOXY-4-METHOXY-BENZENE SULFONAMIDE
  • 2-METHOXY-5-SULPHAMOYLBENZOIC ACID
  • 2-METHOXY-5-SULFONYLBENZOIC ACID
  • 2-METHOXY-5-SULFAMOYLBENZOIC ACID

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