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Sulpiride

CAS No.15676-16-1
Chemical Name:Sulpiride
CBNumber:CB4141314
Molecular Formula:C15H23N3O4S
Formula Weight:341.43
MOL File:15676-16-1.mol

Sulpiride Property

Melting point 178-180°
alpha D25 -66.8° (c = 0.5 in DMF)
Density 1.2375 (rough estimate)
refractive index 1.6320 (estimate)
storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
form powder
pka pKa1 9.00, pKa2 10.19(at 25℃)
color yellow
Water Solubility <0.21g/L(25 ºC)
λmax 232nm(EtOH)(lit.)
Merck 14,8989
InChIKey BGRJTUBHPOOWDU-UHFFFAOYSA-N
LogP 0.57
CAS DataBase Reference 15676-16-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 7MNE9M8287
ATC code N05AL01
NIST Chemistry Reference Sulpiride(15676-16-1)
EPA Substance Registry System Sulpiride (15676-16-1)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :2
RTECS :BZ3400000
HS Code :2933.99.6100
Toxicity :LD50 in mice (mg/kg): 170 i.p.; 2250 orally (Dostert)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H361
Precautionary statements P280

Sulpiride Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: S8010
Product name : (±)-Sulpiride
Purity:
Packaging: 25G
Price: ₹11106.45
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: S8010
Product name : (±)-Sulpiride
Purity:
Packaging: 100G
Price: ₹35235.38
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: S0501
Product name : (±)-Sulpiride
Purity:
Packaging: 5G
Price: ₹3000
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: S0501
Product name : (±)-Sulpiride
Purity:
Packaging: 25G
Price: ₹6000
Updated: 2022/05/26
Buy: Buy

Sulpiride Chemical Properties,Usage,Production

Chemical Properties Sulpiride is White Solid
Originator Dogmatil,Delagrange,France,1969
Uses dopamine receptor antagonist, antipsychotic
Uses Sulpiride possesses moderate neuroleptic activity along with some stimulating and antidepressant effects. It has antiemetic, moderately cataleptogenic, and antiserotonin action. It facilitates increased blood flow in the stomach. It speeds up the restorative processes in tissues. It is used for schizophrenia, depression, migraines, disturbance of behavioral functions, and stomach and duodenal ulcers.
Uses Sulpiride is an antipsychotic drug used in the treatment of Schozophrenia and depression.
Definition Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
Manufacturing Process 1-Ethyl-2-aminomethylpyrrolidine is reacted with 2-methoxy-5- sulfamoylbenzoic acid to give sulpiride.
brand name Dogmatyl (Laboratoires Delagrange, France).
Therapeutic Function Tranquilizer, Digestive aid
Biological Activity Standard D 2 -like dopamine receptor antagonist.
Biochem/physiol Actions (±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46
Clinical Use Antipsychotic:
Acute and chronic schizophrenia
Synthesis Sulpiride, N-[(1-ethyl-2-pirrolidinylmethyl]-5-sulfamoyl-O-anizamide (6.7.2), is synthesized from 5-aminosulfosalycilic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid (6.7.1), which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as amine components and carbonyl-1,1??-bisimidazole as a condensing agent [70¨C74].
Drug interactions Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedativeeffects with opioids; increased risk of ventricular arrhythmias with methadone.
Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide and amiodarone - avoid with amiodarone.
Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin and parenteral erythromycin - avoid with moxifloxacin.
Antidepressants: possibly increased risk of ventricular arrhythmias and antimuscarinic side effects with tricyclics - avoid.
Antiepileptics: antagonism (convulsive threshold lowered).
Antimalarials: avoid with artemether/lumefantrine.
Antipsychotics: increased risk of ventricular arrhythmias with droperidol, haloperidol and pimozide - avoid; possible increased risk of ventricular arrhythmias with risperidone.
Antivirals: concentration possibly increased by ritonavir.
Anxiolytics and hypnotics: increased sedative effects.
Atomoxetine: increased risk of ventricular arrhythmias.
Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol.
Cytotoxics: increased risk of ventricular arrhythmias with vandetanib - avoid; increased risk of ventricular arrhythmias with arsenic trioxide.
Diuretics: enhanced hypotensive effect.
Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.
Pentamidine: increased risk of ventricular arrhythmias.
Metabolism Sulpiride undergoes little metabolism.
95% of a dose is excreted in the urine and faeces, mainly as unchanged drug.
storage Room temperature