ChemicalBook > CAS DataBase List > 5-Bromo-2-methylpyridine

5-Bromo-2-methylpyridine

Description Referrence

CAS No.3430-13-5
Chemical Name:5-Bromo-2-methylpyridine
CBNumber:CB7327298
Molecular Formula:C6H6BrN
Formula Weight:172.02
MOL File:3430-13-5.mol

5-Bromo-2-methylpyridine Property

Melting point 32-36 °C
Boiling point 74 °C / 17mmHg
Density 1.494±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka 3.59±0.10(Predicted)
color Off-White to Light Yellow
BRN 107324
InChI InChI=1S/C6H6BrN/c1-5-2-3-6(7)4-8-5/h2-4H,1H3
InChIKey OFKWIQJLYCKDNY-UHFFFAOYSA-N
SMILES C1(C)=NC=C(Br)C=C1
CAS DataBase Reference 3430-13-5(CAS DataBase Reference)
UNSPSC Code 12352100

Safety

Hazard Codes :Xi,Xn
Risk Statements :36/37/38-20/21/22
Safety Statements :26-36-36/37/39
WGK Germany :3
HazardClass :IRRITANT
HS Code :29333990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335-H301-H311-H332
Precautionary statements P261-P305+P351+P338-P301+P310a-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

5-Bromo-2-methylpyridine Price More Price(3)

Brand: TCI Chemicals (India)
Product number: B2572
Product name : 5-Bromo-2-methylpyridine
Purity: min. 98.0 %
Packaging: 1G
Price: ₹5300
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: B2572
Product name : 5-Bromo-2-methylpyridine
Purity: min. 98.0 %
Packaging: 5G
Price: ₹16000
Updated: 2022/05/26
Buy: Buy

Brand: ALFA India
Product number: ALF-H27085-03
Product name : 5-Bromo-2-methylpyridine, 98%
Purity:
Packaging: 1g
Price: ₹5813
Updated: 2022/05/26
Buy: Buy

5-Bromo-2-methylpyridine Chemical Properties,Usage,Production

Description It is an important intermediate in the organic synthesis, which has many applications, such as pharmaceutical intermediate, organic synthesis, organic solvent, production of dyes, pesticide, and spice. Specifically, this chemical can act as the raw material to prepare 2:2’-dipyridyl and its derivatives.¹ Moreover, this compound may be involved in the synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle.² In addition, 5-bromo-2-methylpyridine has been demonstrated to function as the substrate in a general palladium-catalyzed coupling of aryl bromides/triflates and thiols.³ Besides, this substance can facilitate the synthesis of 5-arylamino-2-picolines via displacement of bromide by anthranilic acid and decarboxylation.⁴
Referrence
1. Willink, H. D. T.; Wibaut, J. P., The preparation of 2 : 2'-dipyridyl and some of its derivatives. Recueil Des Travaux Chimiques Des Pays-Bas 1935, 54, 275-283.
2. Wang, L. H.; Cui, X. L.; Li, J. Y.; Wu, Y. S.; Zhu, Z. W.; Wu, Y. J., Synthesis of Biaryls through a One-Pot Tandem Borylation/Suzuki-Miyaura Cross-Coupling Reaction Catalyzed by a Palladacycle. Eur. J. Org. Chem. 2012, 595-603.
3. Itoh, T.; Mase, T., A general palladium-catalyzed coupling of aryl bromides/triflates and thiols. Org. Lett. 2004, 6, 4587-4590.
4. Louis H. Peterson; Tolman, R. L., Reinvestigation of the synthesis of 5-arylamino-2-picolines J. Heterocycl. Chem. 1977.
Chemical Properties Light yellow Cryst
Uses 5-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.