BI 6015

BI 6015 Property

Boiling point 570.6±60.0 °C(Predicted)
Density 1.45±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
form Beige powder
pka 0.88±0.10(Predicted)
color Tan
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
UNSPSC Code 12352200
NACRES NA.32

Hazard and Precautionary Statements (GHS)

BI 6015 Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: 375240
Product name : HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem
Purity: The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4.
Packaging: 25MG
Price: ₹16090
Updated: 2022/06/14
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BI 6015 Chemical Properties,Usage,Production

Description BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.
Uses BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.
in vivo
BI-6015 (10-30 mg/kg; i.p. once daily for 5 days) induces loss of HNF4α expression and hepatic steatosis in mice^[1].
BI-6015 (10-30 mg/kg; i.p. daily or every other day for 20-57 days) induces apoptosis in a human hepatocellular carcinoma mouse model^[1].
storage Store at -20°C
References 1) Wang et al. (2000), Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion; J. Biol. Chem., 275 35953 2) Kiselyuk et al. (2012), HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promotor; Chem. Biol., 19 806

BI 6015 Preparation Products And Raw materials

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BI 6015 Spectrum

93987-29-2, BI 6015Related Search:

Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
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