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Buparlisib Hydrochloride

Buparlisib Hydrochloride Structure
Buparlisib Hydrochloride
  • CAS No.1312445-63-8
  • Chemical Name:Buparlisib Hydrochloride
  • CBNumber:CB72624269
  • Molecular Formula:C18H22ClF3N6O2
  • Formula Weight:446.86
  • MOL File:1312445-63-8.mol
Buparlisib Hydrochloride Property
  • storage temp. Store at -20°C
  • solubility ≥44.7 mg/mL in DMSO; ≥52.8 mg/mL in H2O with gentle warming; ≥96 mg/mL in EtOH with gentle warming
  • form solid
  • color White to yellow
  • InChI InChI=1S/C18H21F3N6O2.ClH/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27;/h9-11H,1-8H2,(H2,22,23);1H
  • InChIKey DGPLYAXBXJXEID-UHFFFAOYSA-N
  • SMILES C(C1=CC(N)=NC=C1C1=NC(N2CCOCC2)=NC(N2CCOCC2)=C1)(F)(F)F.Cl
  • FDA UNII 194LK4P5K1
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H372-H400-H341-H300-H411
  • Precautionary statements P260-P264-P270-P314-P501-P264-P270-P301+P310-P321-P330-P405-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501

Buparlisib Hydrochloride Chemical Properties,Usage,Production

  • Uses NVP-BKM 120-d16 Hydrochloride is the salt, labeled analogue of NVP-BKM 120 (N925760), a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.
  • Definition Buparlisib hydrochloride (BKM120 Hydrochloride) is an investigational small molecule orally available pan-class I phosphoinositide 3-kinase inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.
  • Mode of action Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase signaling pathway in an ATP-competitive manner, thus inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate and activation of the PI3K signaling pathway. This may induce inhibition of tumour cell growth and survival in susceptible tumour cell populations. Buparlisib is currently under investigation in patients with a variety of solid tumours, including breast cancer[1].
  • References [1] Carmen Criscitiello. “Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date.” Breast Cancer?: Targets and Therapy 10 (2018): 23–29.
Buparlisib Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Buparlisib Hydrochloride Suppliers
Global(93)Suppliers
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    Aladdin Scientific
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    InvivoChem
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Buparlisib Hydrochloride Spectrum
1312445-63-8, Buparlisib HydrochlorideRelated Search:
  • API
  • 抑制剂
  • 柏锦生物
  • 成熟工艺
  • 合成材料中间体
  • 小分子抑制剂
  • 细胞生物学试剂
  • 原料药
  • 化工
  • C18H22ClF3N6O2
  • C18H21F3N6O2HCl
  • 化合物 BUPARLISIB HYDROCHLORIDE
  • 3-氯甲基-2-环丙基-4-(4'-氟苯基)喹啉
  • 布帕西尼盐酸盐 BKM120
  • 盐酸布帕西布
  • 布帕西尼盐酸盐
  • 布帕尼西盐酸盐
  • 泛CLASS IPI3K抑制剂(NVP-BKM120 HYDROCHLORIDE)
  • BKM120(盐酸盐)
  • 1312445-63-8
  • NVP-BKM120 Hydrochloride (Buparlisib HCl)
  • BKM120 HCl (Buparlisib)
  • Buparlisib HCl
  • BKM-120 HYDROCHLORIDE; BKM120 HYDROCHLORIDE; BKM 120 HYDROCHLORIDE
  • BKM-120 HYDROCHLORIDE;BUPARLISIB HYDROCHLORIDE
  • CS-2154
  • NVP-BKM120 (HYDROCHLORI
  • BKM-120 (HCl salt)
  • NVP-BKM120 HCl salt
  • NVP-BKM120 HCl
  • Buparlisib hydrochloride
  • BKM 120AAA
  • 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine hydrochloride (1:1)
  • 5-(2,6-DiMorpholinopyriMidin-4-yl)-4-(trifluoroMethyl)pyridin-2-aMine hydrochloride
  • BKM-120 hydrochloride
  • BKM120 hydrochloride
  • BKM 120 hydrochloride
  • NVP-BKM120 (Hydrochloride)

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