ChemicalBook > CAS DataBase List > (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Structure
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
  • CAS No.314771-76-1
  • Chemical Name:(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine
  • CBNumber:CB72617898
  • Molecular Formula:C18H16ClFN4O2
  • Formula Weight:374.8
  • MOL File:314771-76-1.mol
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Property
  • Boiling point 559.0±50.0 °C(Predicted)
  • Density 1.473±0.06 g/cm3 (20 ºC 760 Torr)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • solubility DMSO (Slightly), Methanol (Slightly, Sonicated, Heated)
  • pka 5.89±0.30(Predicted)
  • form Solid
  • color Light Yellow to Light Beige
  • FDA UNII Q58L53U44Y
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H332-H335
  • Precautionary statements P261-P280-P305+P351+P338

(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Chemical Properties,Usage,Production

  • Uses (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
  • Synthesis To a solution of 4-(3-chloro-4-fluorophenyl)amino-6-nitro-7-[[(S)-tetrahydro-3-furanyl]oxy]- quinazoline (1.34 g, 3.31 mmol) and ammonium chloride (496 mg, 9.27 mmol) in anhydrous DMF (22 mL), Raney nickel [1.5 mL, 50 % (w/v) in water] was added to the reaction mixture and stirred under an atmosphere of hydrogen at 40 °C for 2 h. After 2 h the reaction was diluted with EtOH (10 mL), filtered through diatomaceous earth and washed with a large excess of EtOH. The residue was concentrated under reduced pressure and purified by column chromatography eluting with CHCl3/MeOH (95:5) to give 6 as a viscous brown oil (950 mg, 77 %).
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Suppliers
Global(257)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
(S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine Spectrum
314771-76-1, (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMineRelated Search:
  • 314771-76-1
  • Afatinib Dimaleate
  • 抑制剂
  • 医用原料
  • 杂质-阿法替尼
  • 有机化学
  • 杂质对照品
  • 标准品
  • 化工中间体
  • 对照品-杂质对照品
  • 医药中间体
  • 阿法替尼中间体
  • 马来酸阿法替尼
  • 抗癌类
  • 抗肿瘤
  • 中间体
  • 4-N-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉二胺
  • 化合物 (S)-N4-(3-CHLORO-4-FLUOROPHENYL)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLINE-4,6-DIAMINE
  • 阿法替尼杂质HY
  • (S)-N4-(3-氯-4-氟苯基)-7-[(四氢-3-呋喃基)氧基]-4,6-喹唑啉二胺
  • N-(3-氯-4-氟苯基)-6-硝基-7-[[(3S)-四氢-3-呋喃基]氧基]-4-喹唑啉胺(S)-N4-(3-CHLORO-4-FLUORO-PHENYL)-7-(TETRAHYDRO-FURAN-3-YLOXY)-QUINAZOLINE-4,6-DIAMINE
  • AFTN-1
  • 阿法替尼杂质140
  • 阿法替尼杂质AA1ABCDEFGHJKL
  • N-4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉
  • (S)-N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉二胺
  • 4-[(3-氯-4-氟苯基)氨基]-6-氨基-7-[[(S)-四氢-3-呋喃基]氧基]喹唑啉
  • N-4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-
  • N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4
  • 6-喹唑啉二胺
  • (S)-N4-(3-氯-4-氟苯基)-7-((四氢呋喃-3-基)氧基)喹唑啉-4,6-二胺
  • N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉二胺(阿法替尼中间体) 10G
  • (S)-N4-(3-氯-4-氟苯基)-7-[(四氢-3-呋喃基)氧基]喹唑啉-4,6-二胺
  • N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹
  • N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋...
  • 4-[(3-氯-4-氟苯基)氨基]-6-氨基-7-((S)-四氢呋喃-3-基氧基)-喹唑啉
  • N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉二胺(阿法替尼中间体)
  • N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉二胺
  • 阿法替尼中间体1
  • 阿法替尼中间体 N4-(3-氯-4-氟苯基)-7-[[(3S)-四氢-3-呋喃基]氧基]-4,6-喹唑啉二胺
  • 阿法替尼杂质B
  • 阿法替尼中间体 D
  • 314771-76-1
  • 314771-76-1N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
  • afatinib impurities140
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)...
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamie
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine ISO 9001：2015 REACH
  • Afatinib Impurity 1 ABCDEFGHJKL
  • 3-furanyl]oxy]-4,6-quinazolinediamine
  • S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4
  • (S)-N-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
  • 4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan -3-yl]oxyquinazoline-4,6-diamine
  • (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diammine
  • Afatinib-1
  • 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-[[(S)-tetrahydro-3-furanyl]oxy]quinazoline
  • Afatinib INT
  • N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]

Home

My