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Tak 799

Tak 799 Structure
Tak 799
  • CAS No.229005-80-5
  • Chemical Name:Tak 799
  • CBNumber:CB72497117
  • Molecular Formula:C33H39N2O2.Cl
  • Formula Weight:531.136
  • MOL File:229005-80-5.mol
Tak 799 Property
  • storage temp. 2-8°C
  • solubility H2O: soluble3mg/mL, clear (warmed)
  • form powder
  • color white to beige
  • Water Solubility H2O: 3mg/mL, clear (warmed)
  • FDA UNII BQW1Y9KIIP
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Tak 799 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0911
  • Product name : TAK-779
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹18770.55
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0911
  • Product name : TAK-779
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹72570.8
  • Updated: 2022/06/14
  • Buy: Buy

Tak 799 Chemical Properties,Usage,Production

  • Uses TAK-779 has been used to inhibit CC chemokine ligand 5 (CCL5)– C-C chemokine receptor type 5 (CCR5) interaction in vitro in natural killer (NK) cytotoxicity assay. It has also been used as a blocker of CCR5 to study its effects and to evaluate the opening of the Panx-1 channels on peripheral blood mononuclear cells (PBMCs) isolated from human immunodeficiency virus (HIV)-infected individuals.
  • Biochem/physiol Actions TAK-779 is a potent, dual antagonist at chemokine receptors C-C chemokine receptor type 2 (CCR2) and C-C chemokine receptor type 5 (CCR5) with IC50 = 1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and C-X-C motif chemokine receptor 4 (CXCR4).
  • in vivo

    TAK-779 (10 mg/kg per day, s.c.) significantly prolongs the allograft survival of the rat intestinal transplantation model. TAK-779 also decreases the number of CD4+ as well as CD8+ T cells in spleen, blood and recipient mesenteric lymph nodes (MLN)[2]. TAK-779 (150 μg per mouse, s.c.) supppresses the development of experimental autoimmune encephalomyelitis (EAE) in myelin oligodendrocyte glycoprotein (MOG)-immunized C57BL/6 mice. TAK-779 decreases the infiltration of CXCR3 and CCR5 bearing leukocytes into the spinal cord. TAK-779 does not alter myelin oligodendrocyte glycoprotein (MOG)-specific immune responses or affect the potential of MOG-specific T cells to transfer experimental autoimmune encephalomyelitis (EAE)[3].

  • IC 50 MIP-1α-CCR5: 1 nM (IC50, in CHO/CCR5 cells); MIP-1β-CCR5: 1 nM (IC50, in CHO/CCR5 cells); RANTES-CCR5: 1.4 nM (IC50, in CHO/CCR5 cells); MCP-1-CCR2b: 27 nM (IC50, in CHO/CCR5 cells); R5 HIV-1 (Ba-L): 1.2 nM (EC50, in MAGI-CCR5 cells); R5 HIV-1 (KK): 1.6 nM (EC50, in PBMCs); R5 HIV-1 (HHA): 3.2 nM (EC50, in PBMCs); R5 HIV-1 (CTV): 3.5 nM (EC50, in PBMCs); R5 HIV-1 (Ba-L): 3.7 nM (EC50, in PBMCs); R5 HIV-1 (Ba-L): 5.7 nM (EC90, in MAGI-CCR5 cells); R5 HIV-1 (HHA): 7.5 nM (EC90, in PBMCs); R5 HIV-1 (Ba-L): 12.8 nM (EC90, in PBMCs); R5 HIV-1 (KK): 20.8 nM (EC90, in PBMCs); R5 HIV-1 (CTV): 27 nM (EC90, in PBMCs); mCXCR3: 369 nM (IC50, in PBMCs)
  • storage Store at -20°C
Tak 799 Preparation Products And Raw materials
Raw materials
Preparation Products
Tak 799 Suppliers
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Tak 799 Spectrum
229005-80-5, Tak 799Related Search:
  • 抑制剂
  • 标准品
  • 化合物TAK-779,10 MM DMSO 溶液
  • N-[[4-[6---二羟基-2-(4-甲基苯基)-5H-苯并致苯甲酰-8-基]氨基]苯基]甲基]四羟基-N,N-二甲基-2H-吡喃-4-氯化铵(1:1)
  • N,N-二甲基-N-(4-(2-(对甲苯基)-6,7-二氢-5H-苯并[7]环庚烯-8-甲酰胺基)苄基)四氢-2H-吡喃-4-铵氯化物
  • 化合物TAK-779
  • 229005-80-5
  • TAK-779, 10 mM in DMSO
  • N,N-Dimethyl-N-(4-(2-(p-tolyl)-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride
  • TAK-779,TAK 779,CCR,HIV,Human immunodeficiency virus,Takeda779,Takeda-779,TAK779,CXCR,inhibit,CXC chemokine receptors,CC chemokine receptor,Inhibitor
  • TAK-779 >=98% (HPLC)
  • TAK-779;TAK 779;TAK779
  • CS-2889
  • TAK-779(Cl)
  • TAK-779 Chemical Structure
  • TAK779;TAK 799;TAKEDA 779
  • N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride
  • TAK 799 ;TAK 779
  • Takeda 779
  • Tak 799
  • N,N-Dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-2H-pyran-4-aminium chloride
  • 2H-Pyran-4-aminium, N,N-dimethyl-N-(4-(((2-(4-methylphenyl)-6,7-dihydro-5H-benzocyclohepten-8-yl)carbonyl)amino)benzyl)tetrahydro-, chloride
  • 2H-Oyran-4-aminium, N-((4-(((6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl)carbonyl)amino)phenyl)methyl)tetrahydro-N,N-dimethyl-

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