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Soticlestat

Soticlestat Structure
Soticlestat
  • CAS No.1429505-03-2
  • Chemical Name:Soticlestat
  • CBNumber:CB54668528
  • Molecular Formula:C23H23N3O2
  • Formula Weight:373.45
  • MOL File:1429505-03-2.mol
Soticlestat Property
  • solubility DMSO: soluble
  • form A solid
  • color White to off-white
  • FDA UNII 1766MU795L
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Soticlestat Chemical Properties,Usage,Production

  • Uses Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].
  • in vivo

    Soticlestat treatment lowers brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduceds premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%. Soticlestat can suppress potassium-evoked extracellular glutamate elevations in the hippocampus[1].

    Animal Model:Amyloid precursor protein and presenilin 1 (APP/PS1-Tg) mice (7-week-old)[1]
    Dosage:10 mg/kg
    Administration:Oral administration; once daily; for 1 days, 3 days and 7 days
    Result:Lowered brain 24S-hydroxycholesterol in a dose-dependent manner and substantially reduced premature deaths of APP/PS1-Tg mice at a dose lowering brain 24S-hydroxycholesterol by approximately 50%.
  • References [1] Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. DOI:10.1038/s41598-020-74036-6
    [2] Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. DOI:10.1080/17512433.2019.1605904
Soticlestat Preparation Products And Raw materials
Raw materials
Preparation Products
Soticlestat Suppliers
Global(39)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
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  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
Soticlestat Spectrum
1429505-03-2, SoticlestatRelated Search:
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  • Inhibitor,CYP46A1,inhibit,cholesterol,24-hydroxylase,OV 935,Soticlestat,NMDA,antiepileptic,TAK935,CYPs,epilepsy,TAK 935,Cytochrome P450,OV-935
  • OV935
  • Methanone, [2,4'-bipyridin]-3-yl[4-hydroxy-4-(phenylmethyl)-1-piperidinyl]-
  • TAK-935
  • Soticlestat

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