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COPTISINE

COPTISINE Structure
COPTISINE
  • CAS No.3486-66-6
  • Chemical Name:COPTISINE
  • CBNumber:CB7246829
  • Molecular Formula:C19H14NO4+
  • Formula Weight:320.32
  • MOL File:3486-66-6.mol
COPTISINE Property
  • Melting point 212-217 °C
  • storage temp. Store at 2-8°C
  • solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
  • form Powder
  • FDA UNII 0GCL71VN14
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

COPTISINE Chemical Properties,Usage,Production

  • Uses Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.
  • Definition ChEBI: A natural product found in Coptis japonica.
  • Hazard A poison.
  • Safety Profile A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.
  • in vivo

    Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].

  • IC 50 IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)
  • References [1] Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. DOI:10.3233/JAD-140414
    [2] He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. DOI:10.1007/s11745-014-3983-7
    [3] Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565. DOI:10.1177/1010428317694565
COPTISINE Preparation Products And Raw materials
Raw materials
Preparation Products
COPTISINE Suppliers
Global(153)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29858
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Finetech Industry Limited
  • Tel：+86-27-8746-5837<br/>+8619945049750
  • Email：info@finetechnology-ind.com
  • Country：China
  • ProdList：9642
  • Advantage：58
COPTISINE Spectrum
3486-66-6, COPTISINERelated Search:
  • Alkaloids
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • 抑制剂
  • 中药标准品，对照品
  • 试剂
  • 标准品-中药标准品
  • 化工原料
  • 标准品 -中药标准品
  • 植物提取物
  • 分析标准品
  • 标准品
  • 中药对照品
  • 植提标准品
  • 对照品
  • 中草药成分
  • C19H14NO4
  • 黄连碱,10 MM DMSO 溶液
  • 黄连碱/HPLC
  • 标准品对照品】COPTISINE
  • 黄连碱(对照品)
  • 6,7-二氢-[1,3]二氧戊环并[4',5':7,8]异喹啉并[3,2-A][1,3]二氧戊环并[4,5-G]异喹啉-5-鎓
  • 黄连碱(游离)
  • 黄连碱, 来源于黄连
  • 黄连碱
  • COPTISINE 黄连碱
  • 黃蓮鹼
  • 黄连碱(标准品)
  • 3486-66-6
  • Coptisine, 10 mM in DMSO
  • 6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium
  • 2-Benzenedioic acid
  • COPTISINE USP/EP/BP
  • Coptisine, 98%, from Coptis chinensis Franch.
  • Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-
  • COPTISINE(P)
  • Coptisine Sulfate
  • 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium
  • 5,6-Dihydro-2,3:9,10-bis(methylenedioxy)dibenzo[a,g]quinolizinium
  • Coptisin
  • COPTISINE

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