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GSK-CXCR2

GSK-CXCR2 Structure
GSK-CXCR2
  • CAS No.211096-49-0
  • Chemical Name:GSK-CXCR2
  • CBNumber:CB71872298
  • Molecular Formula:C14H9BrN6O
  • Formula Weight:357.16
  • MOL File:211096-49-0.mol
GSK-CXCR2 Property
  • Boiling point 527.0±45.0 °C(Predicted)
  • Density 1.77±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: soluble15mg/mL, clear
  • pka 6.13±0.40(Predicted)
  • form powder
  • color white to light brown
  • FDA UNII 9P785F0579
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338
GSK-CXCR2 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0421
  • Product name : SB265610
  • Purity: ≥98% (HPLC)
  • Packaging: 5MG
  • Price: ₹15544.7
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: SML0421
  • Product name : SB265610
  • Purity: ≥98% (HPLC)
  • Packaging: 25MG
  • Price: ₹62633.45
  • Updated: 2022/06/14
  • Buy: Buy

GSK-CXCR2 Chemical Properties,Usage,Production

  • Uses SB 265610 is an anti-tumor pharmaceutical developed to act as an antagonist to cysteine-amino acid-cysteine (CXC) chemokines receptor 2 antagonist.
  • Biological Activity Potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca 2+ mobilization (IC 50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
  • Biochem/physiol Actions SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
  • in vivo

    SB-265610 (2 mg/kg/day; i.p.; daily; for two weeks) treatment significantly inhibits the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma with Tgfbr2 deletion but not the control tumors[3].

    Animal Model:MMTV-PyVmT/Tgfbr2MGKO and MMTV-PyVmT/Tgfbr2flox/flox tumors from donor mice[3]
    Dosage:2 mg/kg/day
    Administration:Intraperitoneal injection; daily; for two weeks
    Result:Significantly inhibited the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma.
  • IC 50 CXCR2
  • storage Store at RT
GSK-CXCR2 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-CXCR2 Suppliers
Global(79)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier： Sigma-Aldrich
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GSK-CXCR2 Spectrum
211096-49-0, GSK-CXCR2Related Search:
  • 抑制剂
  • 药靶配体
  • 标准品
  • C14H9BrN6O
  • 化合物SB-265610,10 MM DMSO 溶液
  • 1-(2-溴苯基)-3-(4-氰基-1H-苯并[D][1,2,3]三唑-7-基)脲
  • SB 265610,CXCR2拮抗剂
  • 化合物SB-265610
  • 211096-49-0
  • SB-265610, 10 mM in DMSO
  • CXCR,nonpeptide,inhibit,Inhibitor,SB-265610,inflammation,recruitment,Delay,SB 265610,healing,neutrophil,SB265610,wound,CXC chemokine receptors
  • SB265610 >=98% (HPLC)
  • Urea, N-(2-bromophenyl)-N'-(4-cyano-1H-benzotriazol-7-yl)-
  • 1-(2-Bromophenyl)-3-(4-cyano-1H-benzo[d] [1,2,3]triazol-7-yl)urea
  • SB 265610
  • N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea
  • GSK-CXCR2

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