2-Pyrrolidinone,3-(hydroxymethyl)-1-methyl-(9CI)

Synthesis

577780-04-2

577780-05-3

3-[(Benzyloxy)methyl]-1-methylpyrrolidin-2-one (4.14 g, 18.88 mmol) was used as a raw material and dissolved in methanol (20 mL). Subsequently, 10% aqueous palladium carbon (1.04 g) was added and the reaction mixture was stirred at 0 °C. The reaction mixture was stirred at room temperature for 2 hours under hydrogen atmosphere. Upon completion of the reaction, the palladium carbon catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/methanol (10:1, v/v) to afford 1-methyl-3-(hydroxymethyl)-2-pyrrolidinone (1.55 g, 64% yield) as a colorless oil.1H-NMR (CDCl3) δ: 1.7-1.9 (1H, m), 2.05-2.25 (1H, m), 2.6 -2.8 (1H, m), 2.86 (3H, s), 3.25-3.45 (3H, m), 3.65-3.95 (2H, m).

References