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Columbin

Columbin Structure
Columbin
  • CAS No.546-97-4
  • Chemical Name:Columbin
  • CBNumber:CB71246910
  • Molecular Formula:C20H22O6
  • Formula Weight:358.39
  • MOL File:546-97-4.mol
Columbin Property
  • Melting point 190-191℃
  • alpha D +52.5° (pyridine)
  • Boiling point 410.82°C (rough estimate)
  • Density 1.36
  • refractive index 1.4450 (estimate)
  • storage temp. -20°C
  • solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.03 mg/ml
  • pka 12.14±0.70(Predicted)
  • form Cryst.
  • color White to off-white
  • FDA UNII KKI91P85GE
  • UNSPSC Code 12352205
  • NACRES NA.25
Safety
  • WGK Germany  :3
  • HS Code  :29322090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
Columbin Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SMB00086
  • Product name : Columbin
  • Purity: ≥95% (LC/MS-ELSD)
  • Packaging: 1MG
  • Price: ₹24518.63
  • Updated: 2022/06/14
  • Buy: Buy

Columbin Chemical Properties,Usage,Production

  • Uses Columbin is a furanolactone diterpene isolated from the roots of Jateorhiza and Tinospora species and is used in Asian and African folk medicine for analgesic and antipyretic properties.
  • Definition ChEBI: Columbin is an organic heterotricyclic compound and an organooxygen compound.
  • in vivo

    Columbin inhibits oedema formation in mice paw. At doses of 300 mg/kg and 700 mg/kg, columbin inhibits inflammation from 0 to 5 h and the results are comparable to that of aspirin as a standard anti-inflammatory drug. The inhibitory effect of columbin on carrageenan induced paw oedema in mice may be due to the suppression of the release of mediators responsible for inflammation including prostaglandin[1]. Columbin is poorly bioavailable (2.8% p.o. and 14% i.p.) in rats, but its transport is rapid across the Caco-2 cell monolayers, suggesting that extensive first-pass metabolism in the liver is the likely reason for its poor bioavailability[2].

  • IC 50 Trypanosoma; COX-2: 53.1 μM (EC50); COX-1: 327 μM (EC50)
Columbin Preparation Products And Raw materials
Raw materials
Preparation Products
Columbin Suppliers
Global(135)Suppliers
  • Supplier：
    career henan chemical co
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  • Email：factory@coreychem.com
  • Country：China
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  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
Columbin Spectrum
546-97-4, ColumbinRelated Search:
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  • 古伦宾,10 MM DMSO 溶液
  • 标准品对照品】COLUMBIN
  • 古伦宾(标定对照品)
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  • 古伦宾对照品
  • 非洲防己苦素
  • 青牛胆苦素、黄藤内酯、防己内酯、非洲防己苦素
  • 古伦宾, 来源于青牛胆
  • 古伦宾
  • COLUMBIN 古伦宾
  • 咖伦宾
  • 546-97-4
  • Columbin, 10 mM in DMSO
  • diterpenoid,Cyclooxygenase,anti-inflammatory,COX-1,Inhibitor,Trypanosoma brucei,Columbin,furanolactone,COX,anti-trypanosomal,Parasite,inhibit
  • (2S,4AR,6aR,7R,10R,10aS,10bS)-2-(furan-3-yl)-7-hydroxy-6a,10b-dimethyl-4a,5,6,6a,7,10,10a,10b-octahydro-1H-10,7-(epoxymethano)benzo[f]isochromene-4,12(2H)-dione
  • Columbin USP/EP/BP
  • Columbin >=95% (LC/MS-ELSD)
  • 1,4-Etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione, 9-(3-furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-, (1R,4R,4aR,6aR,9S,10aS,10bS)-
  • (1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione
  • (1R,2S,3S,5S,8R,11R,12R)-5-(3-Furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.0<sup>2,11</sup>.0<sup>3,8</sup>]hexadec-15-ene-7,13-dione
  • Columbin, 98%, from limacia sagittata
  • Tinosporin
  • (1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione
  • (1R,4R,4aR,6aR,9S,10aS,10bS)-9-(3-Furanyl)-1,4,4a,5,6,6a,9,10,10a,10b-decahydro-4-hydroxy-4a,10a-dimethyl-1,4-etheno-3H,7H-benzo[1,2-c:3,4-c']dipyran-3,7-dione
  • (1s,2s,3s,5s,8r,11r,12s)-5-(3-furyl)-12-hydroxy-3,11-dimethyl-6,14-dioxatetracyclo[10.2.2.02,11.03,8]hexadec-15-ene-7,13-dione

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