Chemical Properties
Off-white crystalline powder, easily soluble in methanol, almost insoluble in ether, derived from Gentiana longipedalis (Tibet, Gansu) Gentiana rhizome, Gentiana scabra.
Uses
Gentiopicroside is an anticonvulsant agent present in plant extracts.
Definition
ChEBI: Gentiopicrin is a glycoside.
Biological Activity
Gentiopicroside is an important active component of secoiridoid glycosides from Gentiana macrophylla Pall th at exhibit anti-inflammatory, antibacterial and liver protecting activities. Gentiopicroside protects chondrocytes from IL-1β-induced inflammation response.', 'Gentiopicroside possesses analgesic, anti proliferative, wound healing and antioxidant properties (free radical scavenging activity). Gentiopicroside shows low oral bioavailability, hence it establishes its therapeutic action after metabolism.
Synthesis
Gentiopicroside is isolated from the methanolic root extract of Gentiana kurroo using silica gel and octadecylsilyl (ODS) column chromatography. The concentrated fraction was identified as C16H20O9 (molecular mass 357.1188 g/mol, [M+H]+) by HR-LCMS, FT-IR and 1H-NMR[1].
in vivo
Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice[2].
References
[1]
Sharma, U., Singh, T., Agrawal, V. (2024). Phytochemical Analysis, Isolation, and Characterization of Gentiopicroside from Gentiana kurroo and Cytotoxicity of Biosynthesized Silver Nanoparticles Against HeLa Cells. Applied Biochemistry and Biotechnology, 197(3), 1831–1864.
https://doi.org/10.1007/s12010-024-05114-y
