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MECLOFENAMATE SODIUM

MECLOFENAMATE SODIUM Structure
MECLOFENAMATE SODIUM
  • CAS No.6385-02-0
  • Chemical Name:MECLOFENAMATE SODIUM
  • CBNumber:CB7102365
  • Molecular Formula:C14H10Cl2NO2.Na
  • Formula Weight:318.13
  • MOL File:6385-02-0.mol
MECLOFENAMATE SODIUM Property
  • Melting point 287-291 °C
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form White solid.
  • color White to Off-White
  • biological source synthetic (organic)
  • Water Solubility Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
  • Merck 14,5779
  • Stability Hygroscopic
  • FDA UNII 9MMQ0YER4E
  • NCI Drug Dictionary meclofenamate sodium
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • RTECS  :CB2975500
  • HS Code  :2922498050
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338
MECLOFENAMATE SODIUM Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: M4531
  • Product name : Meclofenamic acid sodium salt
  • Purity: 
  • Packaging: 1G
  • Price: ₹5542.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M4531
  • Product name : Meclofenamic acid sodium salt
  • Purity: 
  • Packaging: 5G
  • Price: ₹16529.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: M1269
  • Product name : Sodium Meclofenamate
  • Purity: 
  • Packaging: 1G
  • Price: ₹3400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: M1269
  • Product name : Sodium Meclofenamate
  • Purity: 
  • Packaging: 10G
  • Price: ₹20500
  • Updated: 2022/05/26
  • Buy: Buy

MECLOFENAMATE SODIUM Chemical Properties,Usage,Production

  • Description Meclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.
  • Originator Meclomen,Warner Lambert,US,1980
  • Uses antiinflammatory, antipyretic
  • Uses Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.
  • Definition ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
  • Indications Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.
  • Manufacturing Process A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
  • brand name Meclomen (Parke-Davis).
  • Therapeutic Function Antiinflammatory
  • General Description Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
  • Pharmacokinetics Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours. Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation. Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of 3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
    Metabolism of meclofenamic acid..jpg
  • Clinical Use Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.
MECLOFENAMATE SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
MECLOFENAMATE SODIUM Suppliers
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MECLOFENAMATE SODIUM Spectrum
6385-02-0, MECLOFENAMATE SODIUMRelated Search:
  • MECLOMEN
  • 抑制剂
  • 生化试剂
  • 标准品
  • 小分子抑制剂
  • 胺
  • Biochemicals and Reagents
  • BioChemical
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • L to O
  • Lipoxygenase (5-) and cyclooxygenase
  • C14H11Cl2NNaO2
  • C14H10Cl2NNaO2xH2O
  • C14H10Cl2NNaO2H2O
  • C14H10Cl2NO2NaH2O
  • 6358-02-0
  • 甲氯灭酸钠,10 MM DMSO 溶液
  • 2-((2,6-二氯-3-甲基苯基)氨基)苯甲酸钠
  • 甲氯灭酸钠 USP标准品
  • 2-(2,6-二氯-3-甲基苯胺基)苯甲酸钠盐
  • 2-[(2,6-二氯-3-甲基苯基)氨基]-苯甲酸钠盐
  • 甲氯芬那酸钠水合物
  • 甲氯灭酸钠/甲氯芬那酸钠/核对
  • 甲氯芬那酸钠盐
  • 甲氯灭酸钠
  • 甲氯芬那酸钠
  • 6385-02-0
  • Meclofenamic acid sodium, 10 mM in DMSO
  • Sodium Meclofenamate Monohydrate, ≥ 98.0%
  • Endogenous Metabolite,Meclofenamate,Inhibitor,Meclofenamic acid sodium,inhibit,Meclofenamic acid,Gap Junction Protein
  • Meclofenamate Sodium (1377803)
  • Meclofenamate Sodium (Meclofenamic acid sodium)
  • MECLOFENAMATE SODIUM USP/EP/BP
  • 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt monohydrate
  • Movens
  • Meclonax
  • SodiumMeclofenamateMonohydrate&gt
  • sodium 2-(2,6-dichloro-3-methylanilino)benzoate hydrate
  • Sodium Meclofenamate Hydrate
  • 2-[(2,6-dichloro-3-methylphenyl)amino]-benzoic acid, sodium salt (1:1)
  • Benzoic acid, 2-[(2,6-dichloro-3-methylphenyl)amino]-, sodium salt (1:1)
  • SodiuM MeclofenaMate&nbsp
  • 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic Acid Sodium Salt Meclofenamic Acid Sodium Salt
  • Meclofenamate Sodium (500 mg)
  • Benzoic acid, 2-[(2,6-dichloro-3-Methylphenyl)aMino]-, sodiuM salt
  • n-(2,6-dichloro-m-tolyl)-anthranilicacimonosodiumsalt
  • meclomen
  • ci583
  • 2-((2,6-dichloro-3-methylphenyl)amino)-benzoicacimonosodiumsalt
  • sodium,2-(2,6-dichloro-3-methylanilino)benzoate
  • 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]BENZOIC ACID SODIUM SALT
  • 2-[(2,6-DICHLORO-3-METHYLPHENYL)AMINO]-BENZOIC ACID, MONOSODIUM SALT
  • MECLOFENAMIC ACID SODIUM SALT
  • MECLOFENAMATE SODIUM SALT
  • MECLOFENAMATE SODIUM HYDRATE
  • MECLOFENAMATE SODIUM

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